Tissue architecture delineates field cancerization in BRAF(V600E)-induced tumor development

Cancer cells hijack developmental growth mechanisms but whether tissue morphogenesis and architecture modify tumorigenesis is unknown. Here, we characterized a new mouse model of sporadic thyroid carcinogenesis based on inducible expression of BRAF carrying a Val600 Glu (V600E) point mutation (BRAFV...

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Detalles Bibliográficos
Autores principales: Schoultz, Elin, Johansson, Ellen, Moccia, Carmen, Jakubikova, Iva, Ravi, Naveen, Liang, Shawn, Carlsson, Therese, Montelius, Mikael, Patyra, Konrad, Kero, Jukka, Paulsson, Kajsa, Fagman, Henrik, Bergo, Martin O., Nilsson, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380047/
https://www.ncbi.nlm.nih.gov/pubmed/34379110
http://dx.doi.org/10.1242/dmm.048887

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