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Outcome of COVID-19 Infection in Cancer Patients in Pune
Introduction We document our data on the course of the coronavirus disease 2019 (COVID-19) infection in cancer patients in an attempt to help optimize their management in India and globally. Material and Methods Between February 2020 and January 2021, participating oncologists from Pune (members o...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Medical and Scientific Publishers Private Ltd
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380150/ https://www.ncbi.nlm.nih.gov/pubmed/34430515 http://dx.doi.org/10.1055/s-0041-1731910 |
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author | Hingmire, Sachin Wategaonkar, Ravikumar Hegde, Sujai Mekha, Mangesh Kulkarni, Rahul Rajbhoj, Ashwin Deshmukh, Chetan Kulkarni, Padmaj Patil, Tushar Kanitkar, Gajanan Wanjarkhedkar, Pankaj Mane, Anupama Bokil, Kamlesh Parasnis, Amit Gawande, Jayant Bhatia, Jatin Khaladkar, Bhagyashree Sirsath, Nagesh Melinkeri, Sameer Kashyapi, Bhalchandra Agrawal, Rakesh Kumar Prabhakaran, Anushree Desai, Isha Kelkar, Dhananjay |
author_facet | Hingmire, Sachin Wategaonkar, Ravikumar Hegde, Sujai Mekha, Mangesh Kulkarni, Rahul Rajbhoj, Ashwin Deshmukh, Chetan Kulkarni, Padmaj Patil, Tushar Kanitkar, Gajanan Wanjarkhedkar, Pankaj Mane, Anupama Bokil, Kamlesh Parasnis, Amit Gawande, Jayant Bhatia, Jatin Khaladkar, Bhagyashree Sirsath, Nagesh Melinkeri, Sameer Kashyapi, Bhalchandra Agrawal, Rakesh Kumar Prabhakaran, Anushree Desai, Isha Kelkar, Dhananjay |
author_sort | Hingmire, Sachin |
collection | PubMed |
description | Introduction We document our data on the course of the coronavirus disease 2019 (COVID-19) infection in cancer patients in an attempt to help optimize their management in India and globally. Material and Methods Between February 2020 and January 2021, participating oncologists from Pune (members of the Oncology Group of Pune) documented effect of COVID-19 infection in their cancer patients. Binomial logistic regression analysis as well as correlation analysis was done using Pearson Chi-square test to determine significance of clinical factors. Results A total of 29 oncologists from 20 hospitals contributed their data involving 147 cancer patients who developed COVID-19 infections. COVID-19 infection resulted in higher deaths (likelihood ratio of 4.4) amongst patients with hematological malignancies (12/44 = 27.2%) as compared with those with solid tumors (13/90 = 14.4%, p = 0.030). Patients with uncontrolled or progressive cancer (11/34 = 32.4%) when they got infected with COVID-19 had higher mortality as compared with patients whose cancer was under control (14/113 = 12.4%; p = 0.020). Complication of thromboembolic episodes (seen in eight patients; 5.4% cases) was associated with higher risk (25.6 times) of death (five-eighths; 62.5%) as compared with those who did not develop it (20/139;14.4%; p <0.001). Discussion Patients with cancer should be advised to take strict precautions to reduce the risk of being infected with COVID-19. They should also be given priority for COVID-19 vaccination. If infected with COVID-19, patients with hematological malignancy and uncontrolled cancer are at higher risk of morbidity and mortality. When they are being treated (OPD or inpatient basis), additional precautions are necessary to ensure their exposure to potential COVID-19 virus is minimized. If they get infected with COVID-19, they should be given aggressive treatment to prevent complications, especially thromboembolic episodes. If they develop any thromboembolic complication, their risk of dying are significantly higher, and management should be modified accordingly. |
format | Online Article Text |
id | pubmed-8380150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Thieme Medical and Scientific Publishers Private Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-83801502021-08-23 Outcome of COVID-19 Infection in Cancer Patients in Pune Hingmire, Sachin Wategaonkar, Ravikumar Hegde, Sujai Mekha, Mangesh Kulkarni, Rahul Rajbhoj, Ashwin Deshmukh, Chetan Kulkarni, Padmaj Patil, Tushar Kanitkar, Gajanan Wanjarkhedkar, Pankaj Mane, Anupama Bokil, Kamlesh Parasnis, Amit Gawande, Jayant Bhatia, Jatin Khaladkar, Bhagyashree Sirsath, Nagesh Melinkeri, Sameer Kashyapi, Bhalchandra Agrawal, Rakesh Kumar Prabhakaran, Anushree Desai, Isha Kelkar, Dhananjay South Asian J Cancer Introduction We document our data on the course of the coronavirus disease 2019 (COVID-19) infection in cancer patients in an attempt to help optimize their management in India and globally. Material and Methods Between February 2020 and January 2021, participating oncologists from Pune (members of the Oncology Group of Pune) documented effect of COVID-19 infection in their cancer patients. Binomial logistic regression analysis as well as correlation analysis was done using Pearson Chi-square test to determine significance of clinical factors. Results A total of 29 oncologists from 20 hospitals contributed their data involving 147 cancer patients who developed COVID-19 infections. COVID-19 infection resulted in higher deaths (likelihood ratio of 4.4) amongst patients with hematological malignancies (12/44 = 27.2%) as compared with those with solid tumors (13/90 = 14.4%, p = 0.030). Patients with uncontrolled or progressive cancer (11/34 = 32.4%) when they got infected with COVID-19 had higher mortality as compared with patients whose cancer was under control (14/113 = 12.4%; p = 0.020). Complication of thromboembolic episodes (seen in eight patients; 5.4% cases) was associated with higher risk (25.6 times) of death (five-eighths; 62.5%) as compared with those who did not develop it (20/139;14.4%; p <0.001). Discussion Patients with cancer should be advised to take strict precautions to reduce the risk of being infected with COVID-19. They should also be given priority for COVID-19 vaccination. If infected with COVID-19, patients with hematological malignancy and uncontrolled cancer are at higher risk of morbidity and mortality. When they are being treated (OPD or inpatient basis), additional precautions are necessary to ensure their exposure to potential COVID-19 virus is minimized. If they get infected with COVID-19, they should be given aggressive treatment to prevent complications, especially thromboembolic episodes. If they develop any thromboembolic complication, their risk of dying are significantly higher, and management should be modified accordingly. Thieme Medical and Scientific Publishers Private Ltd 2021-01 2021-08-21 /pmc/articles/PMC8380150/ /pubmed/34430515 http://dx.doi.org/10.1055/s-0041-1731910 Text en MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Hingmire, Sachin Wategaonkar, Ravikumar Hegde, Sujai Mekha, Mangesh Kulkarni, Rahul Rajbhoj, Ashwin Deshmukh, Chetan Kulkarni, Padmaj Patil, Tushar Kanitkar, Gajanan Wanjarkhedkar, Pankaj Mane, Anupama Bokil, Kamlesh Parasnis, Amit Gawande, Jayant Bhatia, Jatin Khaladkar, Bhagyashree Sirsath, Nagesh Melinkeri, Sameer Kashyapi, Bhalchandra Agrawal, Rakesh Kumar Prabhakaran, Anushree Desai, Isha Kelkar, Dhananjay Outcome of COVID-19 Infection in Cancer Patients in Pune |
title | Outcome of COVID-19 Infection in Cancer Patients in Pune |
title_full | Outcome of COVID-19 Infection in Cancer Patients in Pune |
title_fullStr | Outcome of COVID-19 Infection in Cancer Patients in Pune |
title_full_unstemmed | Outcome of COVID-19 Infection in Cancer Patients in Pune |
title_short | Outcome of COVID-19 Infection in Cancer Patients in Pune |
title_sort | outcome of covid-19 infection in cancer patients in pune |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380150/ https://www.ncbi.nlm.nih.gov/pubmed/34430515 http://dx.doi.org/10.1055/s-0041-1731910 |
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