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Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat

Reactive oxygen species (ROS) are essential for cellular signaling and response to stress. The level of ROS and the type of ROS determine the ability of cells to undergo cell death. Furthermore, dysregulation of the antioxidant pathways is associated with many diseases. It has become apparent that c...

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Autores principales: Villalpando-Rodriguez, Gloria E., Gibson, Spencer B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380163/
https://www.ncbi.nlm.nih.gov/pubmed/34426760
http://dx.doi.org/10.1155/2021/9912436
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author Villalpando-Rodriguez, Gloria E.
Gibson, Spencer B.
author_facet Villalpando-Rodriguez, Gloria E.
Gibson, Spencer B.
author_sort Villalpando-Rodriguez, Gloria E.
collection PubMed
description Reactive oxygen species (ROS) are essential for cellular signaling and response to stress. The level of ROS and the type of ROS determine the ability of cells to undergo cell death. Furthermore, dysregulation of the antioxidant pathways is associated with many diseases. It has become apparent that cell death can occur through different mechanisms leading to the classifications of different types of cell death such as apoptosis, ferroptosis, and necroptosis. ROS play essential roles in all forms of cell death, but it is only now coming into focus that ROS control and determine the type of cell death that occurs in any given cell. Indeed, ROS may act as a rheostat allowing different cell death mechanisms to be engaged and crosstalk with different cell death types. In this review, we will describe the ROS regulatory pathways and how they control different types of cell death under normal and disease states. We will also propose how ROS could provide a mechanism of crosstalk between cell death mechanisms and act as a rheostat determining the type of cell death.
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spelling pubmed-83801632021-08-22 Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat Villalpando-Rodriguez, Gloria E. Gibson, Spencer B. Oxid Med Cell Longev Review Article Reactive oxygen species (ROS) are essential for cellular signaling and response to stress. The level of ROS and the type of ROS determine the ability of cells to undergo cell death. Furthermore, dysregulation of the antioxidant pathways is associated with many diseases. It has become apparent that cell death can occur through different mechanisms leading to the classifications of different types of cell death such as apoptosis, ferroptosis, and necroptosis. ROS play essential roles in all forms of cell death, but it is only now coming into focus that ROS control and determine the type of cell death that occurs in any given cell. Indeed, ROS may act as a rheostat allowing different cell death mechanisms to be engaged and crosstalk with different cell death types. In this review, we will describe the ROS regulatory pathways and how they control different types of cell death under normal and disease states. We will also propose how ROS could provide a mechanism of crosstalk between cell death mechanisms and act as a rheostat determining the type of cell death. Hindawi 2021-08-14 /pmc/articles/PMC8380163/ /pubmed/34426760 http://dx.doi.org/10.1155/2021/9912436 Text en Copyright © 2021 Gloria E. Villalpando-Rodriguez and Spencer B. Gibson. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Villalpando-Rodriguez, Gloria E.
Gibson, Spencer B.
Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat
title Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat
title_full Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat
title_fullStr Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat
title_full_unstemmed Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat
title_short Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat
title_sort reactive oxygen species (ros) regulates different types of cell death by acting as a rheostat
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380163/
https://www.ncbi.nlm.nih.gov/pubmed/34426760
http://dx.doi.org/10.1155/2021/9912436
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