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Differences in P-glycoprotein activity in human and rodent blood–brain barrier assessed by mechanistic modelling
Variation in the efficacy and safety of central nervous system drugs between humans and rodents can be explained by physiological differences between species. An important factor could be P-glycoprotein (Pgp) activity in the blood–brain barrier (BBB), as BBB expression of this drug efflux transporte...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380243/ https://www.ncbi.nlm.nih.gov/pubmed/34268580 http://dx.doi.org/10.1007/s00204-021-03115-y |