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Safety, Virologic Efficacy, and Pharmacokinetics of CT-P59, a Neutralizing Monoclonal Antibody Against SARS-CoV-2 Spike Receptor-Binding Protein: Two Randomized, Placebo-Controlled, Phase I Studies in Healthy Individuals and Patients With Mild SARS-CoV-2 Infection
PURPOSE: Neutralizing antibodies can reduce SARS-CoV-2 cellular entry, viral titers, and pathologic damage. CT-P59 (regdanvimab), a SARS-CoV-2 neutralizing monoclonal antibody, was examined in 2 randomized, double-blind, placebo-controlled, single ascending dose, Phase I studies. METHODS: In study 1...
Autores principales: | Kim, Jin Yong, Jang, Young Rock, Hong, Jang Hee, Jung, Jin Gyu, Park, Jae-Hyeong, Streinu-Cercel, Adrian, Streinu-Cercel, Anca, Săndulescu, Oana, Lee, Sang Joon, Kim, Sung Hyun, Jung, Na Hyun, Lee, Seul Gi, Park, Jeong Eun, Kim, Min Kyung, Jeon, Da Bee, Lee, Yeo Jin, Kim, Bum Soo, Lee, Yeon Mi, Kim, Yeon-Sook |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380488/ https://www.ncbi.nlm.nih.gov/pubmed/34551869 http://dx.doi.org/10.1016/j.clinthera.2021.08.009 |
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