Cargando…
Pain Medication and Corticosteroid Use in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis in the United States: A Retrospective Observational Study
OBJECTIVE: We compared pain medication use in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis (RA) versus matched control over 2 years; a subgroup analysis assessed changes in pain medication use in patients who initiated a biologic during 12 months bef...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380595/ https://www.ncbi.nlm.nih.gov/pubmed/34312825 http://dx.doi.org/10.1007/s40744-021-00344-6 |
_version_ | 1783741228700925952 |
---|---|
author | Hunter, Theresa Nguyen, Chi Birt, Julie Smith, Joseph Shan, Mingyang Tan, Hiangkiat Lisse, Jeffrey Isenberg, Keith |
author_facet | Hunter, Theresa Nguyen, Chi Birt, Julie Smith, Joseph Shan, Mingyang Tan, Hiangkiat Lisse, Jeffrey Isenberg, Keith |
author_sort | Hunter, Theresa |
collection | PubMed |
description | OBJECTIVE: We compared pain medication use in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis (RA) versus matched control over 2 years; a subgroup analysis assessed changes in pain medication use in patients who initiated a biologic during 12 months before and after. METHODS: This was a retrospective observational cohort study using an administrative claims database. Newly diagnosed adult patients with AS, PsA, or RA identified between 1/1/2014 and 7/31/2017 were included. Demographics, baseline characteristics, and pain medication use were described using descriptive statistics. Differences in pain medication use were assessed using McNemar's/Wilcoxon signed-rank test for categorical/continuous variables. RESULTS: The study included 2180 AS, 5681 PsA, and 34,047 RA patients to assess overall pain medication use over 2 years; 188 AS, 921 PsA, and 1599 RA patients were included to assess changes in pain medication use 12 months before and after initiation of biologic. Demographics and baseline characteristics were balanced. In the overall cohort, 74.6% AS, 75.0% PsA, and 83.0% RA patients used any pain medication at baseline versus matched control; pain medications use 2 years after diagnosis date was reported in 73.5% AS, 74.1% PsA, and 81.3% RA patients. Among AS, PsA, and RA patients, use of prescribed NSAIDs (AS: 68.1 vs. 51.1%; PsA: 51.1 vs. 42.5%; RA: 61.1 vs. 41.5%; P < 0.05), glucocorticoids (AS: 56.4 vs. 41.5%; PsA: 57.4 vs. 46.9%; RA: 88.2 vs. 75.3%; P < 0.05), and opioids (AS: 42.6 vs. 36.2% [non-significant]; PsA: 38.1 vs. 33.8%; RA: 52.0 vs. 40.4%; P < 0.05) significantly decreased 12 months after biologic initiation versus prior. CONCLUSIONS: Use of NSAIDs, glucocorticoids, and opioids are common among patients with AS, PsA, or RA, although the reported use of these co-medications after biologic initiation significantly decreases in the first year of treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40744-021-00344-6. |
format | Online Article Text |
id | pubmed-8380595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-83805952021-09-08 Pain Medication and Corticosteroid Use in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis in the United States: A Retrospective Observational Study Hunter, Theresa Nguyen, Chi Birt, Julie Smith, Joseph Shan, Mingyang Tan, Hiangkiat Lisse, Jeffrey Isenberg, Keith Rheumatol Ther Original Research OBJECTIVE: We compared pain medication use in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis (RA) versus matched control over 2 years; a subgroup analysis assessed changes in pain medication use in patients who initiated a biologic during 12 months before and after. METHODS: This was a retrospective observational cohort study using an administrative claims database. Newly diagnosed adult patients with AS, PsA, or RA identified between 1/1/2014 and 7/31/2017 were included. Demographics, baseline characteristics, and pain medication use were described using descriptive statistics. Differences in pain medication use were assessed using McNemar's/Wilcoxon signed-rank test for categorical/continuous variables. RESULTS: The study included 2180 AS, 5681 PsA, and 34,047 RA patients to assess overall pain medication use over 2 years; 188 AS, 921 PsA, and 1599 RA patients were included to assess changes in pain medication use 12 months before and after initiation of biologic. Demographics and baseline characteristics were balanced. In the overall cohort, 74.6% AS, 75.0% PsA, and 83.0% RA patients used any pain medication at baseline versus matched control; pain medications use 2 years after diagnosis date was reported in 73.5% AS, 74.1% PsA, and 81.3% RA patients. Among AS, PsA, and RA patients, use of prescribed NSAIDs (AS: 68.1 vs. 51.1%; PsA: 51.1 vs. 42.5%; RA: 61.1 vs. 41.5%; P < 0.05), glucocorticoids (AS: 56.4 vs. 41.5%; PsA: 57.4 vs. 46.9%; RA: 88.2 vs. 75.3%; P < 0.05), and opioids (AS: 42.6 vs. 36.2% [non-significant]; PsA: 38.1 vs. 33.8%; RA: 52.0 vs. 40.4%; P < 0.05) significantly decreased 12 months after biologic initiation versus prior. CONCLUSIONS: Use of NSAIDs, glucocorticoids, and opioids are common among patients with AS, PsA, or RA, although the reported use of these co-medications after biologic initiation significantly decreases in the first year of treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40744-021-00344-6. Springer Healthcare 2021-07-26 /pmc/articles/PMC8380595/ /pubmed/34312825 http://dx.doi.org/10.1007/s40744-021-00344-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Hunter, Theresa Nguyen, Chi Birt, Julie Smith, Joseph Shan, Mingyang Tan, Hiangkiat Lisse, Jeffrey Isenberg, Keith Pain Medication and Corticosteroid Use in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis in the United States: A Retrospective Observational Study |
title | Pain Medication and Corticosteroid Use in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis in the United States: A Retrospective Observational Study |
title_full | Pain Medication and Corticosteroid Use in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis in the United States: A Retrospective Observational Study |
title_fullStr | Pain Medication and Corticosteroid Use in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis in the United States: A Retrospective Observational Study |
title_full_unstemmed | Pain Medication and Corticosteroid Use in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis in the United States: A Retrospective Observational Study |
title_short | Pain Medication and Corticosteroid Use in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis in the United States: A Retrospective Observational Study |
title_sort | pain medication and corticosteroid use in ankylosing spondylitis, psoriatic arthritis, and rheumatoid arthritis in the united states: a retrospective observational study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380595/ https://www.ncbi.nlm.nih.gov/pubmed/34312825 http://dx.doi.org/10.1007/s40744-021-00344-6 |
work_keys_str_mv | AT huntertheresa painmedicationandcorticosteroiduseinankylosingspondylitispsoriaticarthritisandrheumatoidarthritisintheunitedstatesaretrospectiveobservationalstudy AT nguyenchi painmedicationandcorticosteroiduseinankylosingspondylitispsoriaticarthritisandrheumatoidarthritisintheunitedstatesaretrospectiveobservationalstudy AT birtjulie painmedicationandcorticosteroiduseinankylosingspondylitispsoriaticarthritisandrheumatoidarthritisintheunitedstatesaretrospectiveobservationalstudy AT smithjoseph painmedicationandcorticosteroiduseinankylosingspondylitispsoriaticarthritisandrheumatoidarthritisintheunitedstatesaretrospectiveobservationalstudy AT shanmingyang painmedicationandcorticosteroiduseinankylosingspondylitispsoriaticarthritisandrheumatoidarthritisintheunitedstatesaretrospectiveobservationalstudy AT tanhiangkiat painmedicationandcorticosteroiduseinankylosingspondylitispsoriaticarthritisandrheumatoidarthritisintheunitedstatesaretrospectiveobservationalstudy AT lissejeffrey painmedicationandcorticosteroiduseinankylosingspondylitispsoriaticarthritisandrheumatoidarthritisintheunitedstatesaretrospectiveobservationalstudy AT isenbergkeith painmedicationandcorticosteroiduseinankylosingspondylitispsoriaticarthritisandrheumatoidarthritisintheunitedstatesaretrospectiveobservationalstudy |