Thioredoxin Reductase is a major regulator of metabolism in leukemia cells

Despite the fact that AML is the most common acute leukemia in adults, patient outcomes are poor necessitating the development of novel therapies. We identified that inhibition of Thioredoxin Reductase (TrxR) is a promising strategy for AML and report a highly potent and specific inhibitor of TrxR,...

Descripción completa

Detalles Bibliográficos
Autores principales: Karunanithi, Sheelarani, Liu, Ruifu, Hou, Yongchun, Gonzalez, Giancarlo, Oldford, Natasha, Roe, Anne Jessica, Idipilly, Nethrie, Gupta, Kalpana, Amara, Chandra Sekhar, Putluri, Satwikreddy, Lee, Grace Kyueun, Valentin-Goyco, Juan, Stetson, Lindsay, Moreton, Stephen A, Putluri, Vasanta, Kavuri, Shyam M, Saunthararajah, Yogen, de Lima, Marcos, Tochtrop, Gregory P, Putluri, Nagireddy, Wald, David N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380733/
https://www.ncbi.nlm.nih.gov/pubmed/34239044
http://dx.doi.org/10.1038/s41388-021-01924-0

Ejemplares similares

Ejemplares similares