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Associations of Dietary Fat Intake With Mortality From All Causes, Cardiovascular Disease, and Cancer: A Prospective Study
The impact of fat intake on health has become a growing public concern. The existing evidence linking specific dietary fat intake with mortality is controversial. We aimed to investigate the association between fat intake and total and cause-specific mortality in the Prostate, Lung, Colorectal, and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380819/ https://www.ncbi.nlm.nih.gov/pubmed/34434952 http://dx.doi.org/10.3389/fnut.2021.701430 |
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author | Yao, Xiaolin Xu, Xin Wang, Shuo Xia, Dan |
author_facet | Yao, Xiaolin Xu, Xin Wang, Shuo Xia, Dan |
author_sort | Yao, Xiaolin |
collection | PubMed |
description | The impact of fat intake on health has become a growing public concern. The existing evidence linking specific dietary fat intake with mortality is controversial. We aimed to investigate the association between fat intake and total and cause-specific mortality in the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial. Intakes of saturated fatty acids (SFAs), trans-fatty acids (TFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) were assessed via food frequency questionnaires. The primary outcomes were total, cardiovascular disease (CVD), and cancer mortality. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression model adjusting for confounders. Overall, 24,141 deaths were recorded over a total 1,672,715 person-years of follow-up. There was a significant positive association between SFA consumption and total mortality (HR(Q5 vs. Q1) = 1.13, 95% CI 1.05–1.22; P(for trend) < 0.001). PUFA intake was strongly inversely associated with total mortality (HR(Q5 vs. Q1) = 0.79, 95% CI 0.73–0.85; P(for trend) < 0.001) and CVD mortality (HR(Q5 vs. Q1) = 0.66, 95% CI 0.58–0.75; P(for trend) < 0.001). There was a similar, but to a lesser extent, association between MUFA intake and total and CVD mortality [HR(Q5 vs. Q1) 0.91 (95% CI: 0.84–0.99), P(for trend) = 0.044 and 0.85 (0.73–0.98), P(for trend) = 0.020, respectively]. None of these types of dietary fat were associated with cancer mortality (all P(for trend) > 0.05). In conclusion, this study observed a detrimental effect of SFA intake on total mortality; in contrast, greater consumption of PUFAs and MUFAs were associated with lower risks of all-cause death and CVD mortality. |
format | Online Article Text |
id | pubmed-8380819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83808192021-08-24 Associations of Dietary Fat Intake With Mortality From All Causes, Cardiovascular Disease, and Cancer: A Prospective Study Yao, Xiaolin Xu, Xin Wang, Shuo Xia, Dan Front Nutr Nutrition The impact of fat intake on health has become a growing public concern. The existing evidence linking specific dietary fat intake with mortality is controversial. We aimed to investigate the association between fat intake and total and cause-specific mortality in the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial. Intakes of saturated fatty acids (SFAs), trans-fatty acids (TFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) were assessed via food frequency questionnaires. The primary outcomes were total, cardiovascular disease (CVD), and cancer mortality. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression model adjusting for confounders. Overall, 24,141 deaths were recorded over a total 1,672,715 person-years of follow-up. There was a significant positive association between SFA consumption and total mortality (HR(Q5 vs. Q1) = 1.13, 95% CI 1.05–1.22; P(for trend) < 0.001). PUFA intake was strongly inversely associated with total mortality (HR(Q5 vs. Q1) = 0.79, 95% CI 0.73–0.85; P(for trend) < 0.001) and CVD mortality (HR(Q5 vs. Q1) = 0.66, 95% CI 0.58–0.75; P(for trend) < 0.001). There was a similar, but to a lesser extent, association between MUFA intake and total and CVD mortality [HR(Q5 vs. Q1) 0.91 (95% CI: 0.84–0.99), P(for trend) = 0.044 and 0.85 (0.73–0.98), P(for trend) = 0.020, respectively]. None of these types of dietary fat were associated with cancer mortality (all P(for trend) > 0.05). In conclusion, this study observed a detrimental effect of SFA intake on total mortality; in contrast, greater consumption of PUFAs and MUFAs were associated with lower risks of all-cause death and CVD mortality. Frontiers Media S.A. 2021-08-09 /pmc/articles/PMC8380819/ /pubmed/34434952 http://dx.doi.org/10.3389/fnut.2021.701430 Text en Copyright © 2021 Yao, Xu, Wang and Xia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Yao, Xiaolin Xu, Xin Wang, Shuo Xia, Dan Associations of Dietary Fat Intake With Mortality From All Causes, Cardiovascular Disease, and Cancer: A Prospective Study |
title | Associations of Dietary Fat Intake With Mortality From All Causes, Cardiovascular Disease, and Cancer: A Prospective Study |
title_full | Associations of Dietary Fat Intake With Mortality From All Causes, Cardiovascular Disease, and Cancer: A Prospective Study |
title_fullStr | Associations of Dietary Fat Intake With Mortality From All Causes, Cardiovascular Disease, and Cancer: A Prospective Study |
title_full_unstemmed | Associations of Dietary Fat Intake With Mortality From All Causes, Cardiovascular Disease, and Cancer: A Prospective Study |
title_short | Associations of Dietary Fat Intake With Mortality From All Causes, Cardiovascular Disease, and Cancer: A Prospective Study |
title_sort | associations of dietary fat intake with mortality from all causes, cardiovascular disease, and cancer: a prospective study |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380819/ https://www.ncbi.nlm.nih.gov/pubmed/34434952 http://dx.doi.org/10.3389/fnut.2021.701430 |
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