Risk Factors for Development and Severity of COVID-19 in COPD Patients

The impact that COVID-19 could have on patients with COPD is a real concern. In this study we evaluated, in a cohort of longitudinally followed COPD subjects, the incidence of COVID-19, seeking for possible risk factors and prognostic factors predicting the clinical outcome. In our cohort of 370 pat...

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Autores principales: Bonato, Matteo, Semenzato, Umberto, Tinè, Mariaenrica, Bazzan, Erica, Damin, Marco, Biondini, Davide, Casara, Alvise, Romagnoli, Micaela, Turato, Graziella, Cosio, Manuel G., Saetta, Marina, Baraldo, Simonetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380950/
https://www.ncbi.nlm.nih.gov/pubmed/34434947
http://dx.doi.org/10.3389/fmed.2021.714570
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author Bonato, Matteo
Semenzato, Umberto
Tinè, Mariaenrica
Bazzan, Erica
Damin, Marco
Biondini, Davide
Casara, Alvise
Romagnoli, Micaela
Turato, Graziella
Cosio, Manuel G.
Saetta, Marina
Baraldo, Simonetta
author_facet Bonato, Matteo
Semenzato, Umberto
Tinè, Mariaenrica
Bazzan, Erica
Damin, Marco
Biondini, Davide
Casara, Alvise
Romagnoli, Micaela
Turato, Graziella
Cosio, Manuel G.
Saetta, Marina
Baraldo, Simonetta
author_sort Bonato, Matteo
collection PubMed
description The impact that COVID-19 could have on patients with COPD is a real concern. In this study we evaluated, in a cohort of longitudinally followed COPD subjects, the incidence of COVID-19, seeking for possible risk factors and prognostic factors predicting the clinical outcome. In our cohort of 370 patients (followed for 5.3 ± 2.7 years), 22 developed COVID-19 (COPD/COVID-19+) between February/November 2020 (5.9%). Cardio-metabolic conditions (hypertension, dyslipidemia, obesity, diabetes) but not respiratory abnormalities (FEV(1), DLCO, emphysema and exacerbation history), were risk factors for development of COVID-19 in COPD patients. Out of the 22 COPD/COVID-19+ patients, 10 needed intensive care. Low DLCO and emphysema, but also metabolic comorbidities, were related to the need for intensive care.
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spelling pubmed-83809502021-08-24 Risk Factors for Development and Severity of COVID-19 in COPD Patients Bonato, Matteo Semenzato, Umberto Tinè, Mariaenrica Bazzan, Erica Damin, Marco Biondini, Davide Casara, Alvise Romagnoli, Micaela Turato, Graziella Cosio, Manuel G. Saetta, Marina Baraldo, Simonetta Front Med (Lausanne) Medicine The impact that COVID-19 could have on patients with COPD is a real concern. In this study we evaluated, in a cohort of longitudinally followed COPD subjects, the incidence of COVID-19, seeking for possible risk factors and prognostic factors predicting the clinical outcome. In our cohort of 370 patients (followed for 5.3 ± 2.7 years), 22 developed COVID-19 (COPD/COVID-19+) between February/November 2020 (5.9%). Cardio-metabolic conditions (hypertension, dyslipidemia, obesity, diabetes) but not respiratory abnormalities (FEV(1), DLCO, emphysema and exacerbation history), were risk factors for development of COVID-19 in COPD patients. Out of the 22 COPD/COVID-19+ patients, 10 needed intensive care. Low DLCO and emphysema, but also metabolic comorbidities, were related to the need for intensive care. Frontiers Media S.A. 2021-08-09 /pmc/articles/PMC8380950/ /pubmed/34434947 http://dx.doi.org/10.3389/fmed.2021.714570 Text en Copyright © 2021 Bonato, Semenzato, Tinè, Bazzan, Damin, Biondini, Casara, Romagnoli, Turato, Cosio, Saetta and Baraldo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Bonato, Matteo
Semenzato, Umberto
Tinè, Mariaenrica
Bazzan, Erica
Damin, Marco
Biondini, Davide
Casara, Alvise
Romagnoli, Micaela
Turato, Graziella
Cosio, Manuel G.
Saetta, Marina
Baraldo, Simonetta
Risk Factors for Development and Severity of COVID-19 in COPD Patients
title Risk Factors for Development and Severity of COVID-19 in COPD Patients
title_full Risk Factors for Development and Severity of COVID-19 in COPD Patients
title_fullStr Risk Factors for Development and Severity of COVID-19 in COPD Patients
title_full_unstemmed Risk Factors for Development and Severity of COVID-19 in COPD Patients
title_short Risk Factors for Development and Severity of COVID-19 in COPD Patients
title_sort risk factors for development and severity of covid-19 in copd patients
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380950/
https://www.ncbi.nlm.nih.gov/pubmed/34434947
http://dx.doi.org/10.3389/fmed.2021.714570
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