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Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study
BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) in Saudi Arabia is predicted to exceed 30% by 2030. NAFLD leads to liver fibrosis, thus increasing morbidity and health care burden. Obesity and diabetes have been strongly associated with NAFLD in different cities in Saudi Arabi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381033/ https://www.ncbi.nlm.nih.gov/pubmed/34466067 http://dx.doi.org/10.1016/j.sjbs.2021.05.063 |
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author | Alamri, Abdulhakeem S. Alhomrani, Majid Alsanie, Walaa F. Alghamdi, Ahmad Joman Alghamdi, Zaher M. Al-Subaie, Abdualmohsen A. Alharthi, Yasser A. Alqurashi, Hesham H. Asdaq, Syed Mohammed Basheeruddin |
author_facet | Alamri, Abdulhakeem S. Alhomrani, Majid Alsanie, Walaa F. Alghamdi, Ahmad Joman Alghamdi, Zaher M. Al-Subaie, Abdualmohsen A. Alharthi, Yasser A. Alqurashi, Hesham H. Asdaq, Syed Mohammed Basheeruddin |
author_sort | Alamri, Abdulhakeem S. |
collection | PubMed |
description | BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) in Saudi Arabia is predicted to exceed 30% by 2030. NAFLD leads to liver fibrosis, thus increasing morbidity and health care burden. Obesity and diabetes have been strongly associated with NAFLD in different cities in Saudi Arabia. OBJECTIVES: Therefore, we aim to determine the prevalence rate of NAFLD and specific risk factors for NAFLD among patients of tertiary care hospital of Taif city. MATERIAL AND METHODS: We retrospectively analyzed the medical records of patients for two years, between Feb 2017 and Feb 2019, (n = 100) referred to the hepatology clinic at King Abdulaziz Specialist Hospital in Taif. The diagnosis of NAFLD was based on the radiology report for patients who were aged >20 years old. Other parameters including fasting blood glucose (FBG), platelets count, alanine transaminase (ALT), aspartate transaminase (AST) and total bilirubin were statistically analyzed. RESULTS: We found that 40% (P < 0.05) of all patients had NAFLD. The results revealed that a significantly high number of patients with NAFLD have high FBG levels (75%, P < 0.0001) and total bilirubin (P < 0.05). Meanwhile, platelet count was significantly reduced in patients with NAFLD (P < 0.05). CONCLUSION: NAFLD can be a serious health problem in the Taif region. In addition, high FBG is a significant specific risk factor for NAFLD. Health care providers should pay more attention to limiting the prevalence of NAFLD and its risk factors. |
format | Online Article Text |
id | pubmed-8381033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83810332021-08-30 Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study Alamri, Abdulhakeem S. Alhomrani, Majid Alsanie, Walaa F. Alghamdi, Ahmad Joman Alghamdi, Zaher M. Al-Subaie, Abdualmohsen A. Alharthi, Yasser A. Alqurashi, Hesham H. Asdaq, Syed Mohammed Basheeruddin Saudi J Biol Sci Original Article BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) in Saudi Arabia is predicted to exceed 30% by 2030. NAFLD leads to liver fibrosis, thus increasing morbidity and health care burden. Obesity and diabetes have been strongly associated with NAFLD in different cities in Saudi Arabia. OBJECTIVES: Therefore, we aim to determine the prevalence rate of NAFLD and specific risk factors for NAFLD among patients of tertiary care hospital of Taif city. MATERIAL AND METHODS: We retrospectively analyzed the medical records of patients for two years, between Feb 2017 and Feb 2019, (n = 100) referred to the hepatology clinic at King Abdulaziz Specialist Hospital in Taif. The diagnosis of NAFLD was based on the radiology report for patients who were aged >20 years old. Other parameters including fasting blood glucose (FBG), platelets count, alanine transaminase (ALT), aspartate transaminase (AST) and total bilirubin were statistically analyzed. RESULTS: We found that 40% (P < 0.05) of all patients had NAFLD. The results revealed that a significantly high number of patients with NAFLD have high FBG levels (75%, P < 0.0001) and total bilirubin (P < 0.05). Meanwhile, platelet count was significantly reduced in patients with NAFLD (P < 0.05). CONCLUSION: NAFLD can be a serious health problem in the Taif region. In addition, high FBG is a significant specific risk factor for NAFLD. Health care providers should pay more attention to limiting the prevalence of NAFLD and its risk factors. Elsevier 2021-09 2021-06-01 /pmc/articles/PMC8381033/ /pubmed/34466067 http://dx.doi.org/10.1016/j.sjbs.2021.05.063 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Alamri, Abdulhakeem S. Alhomrani, Majid Alsanie, Walaa F. Alghamdi, Ahmad Joman Alghamdi, Zaher M. Al-Subaie, Abdualmohsen A. Alharthi, Yasser A. Alqurashi, Hesham H. Asdaq, Syed Mohammed Basheeruddin Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study |
title | Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study |
title_full | Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study |
title_fullStr | Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study |
title_full_unstemmed | Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study |
title_short | Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study |
title_sort | prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of taif, saudi arabia: a retrospective study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381033/ https://www.ncbi.nlm.nih.gov/pubmed/34466067 http://dx.doi.org/10.1016/j.sjbs.2021.05.063 |
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