Cargando…

Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study

BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) in Saudi Arabia is predicted to exceed 30% by 2030. NAFLD leads to liver fibrosis, thus increasing morbidity and health care burden. Obesity and diabetes have been strongly associated with NAFLD in different cities in Saudi Arabi...

Descripción completa

Detalles Bibliográficos
Autores principales: Alamri, Abdulhakeem S., Alhomrani, Majid, Alsanie, Walaa F., Alghamdi, Ahmad Joman, Alghamdi, Zaher M., Al-Subaie, Abdualmohsen A., Alharthi, Yasser A., Alqurashi, Hesham H., Asdaq, Syed Mohammed Basheeruddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381033/
https://www.ncbi.nlm.nih.gov/pubmed/34466067
http://dx.doi.org/10.1016/j.sjbs.2021.05.063
_version_ 1783741287866826752
author Alamri, Abdulhakeem S.
Alhomrani, Majid
Alsanie, Walaa F.
Alghamdi, Ahmad Joman
Alghamdi, Zaher M.
Al-Subaie, Abdualmohsen A.
Alharthi, Yasser A.
Alqurashi, Hesham H.
Asdaq, Syed Mohammed Basheeruddin
author_facet Alamri, Abdulhakeem S.
Alhomrani, Majid
Alsanie, Walaa F.
Alghamdi, Ahmad Joman
Alghamdi, Zaher M.
Al-Subaie, Abdualmohsen A.
Alharthi, Yasser A.
Alqurashi, Hesham H.
Asdaq, Syed Mohammed Basheeruddin
author_sort Alamri, Abdulhakeem S.
collection PubMed
description BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) in Saudi Arabia is predicted to exceed 30% by 2030. NAFLD leads to liver fibrosis, thus increasing morbidity and health care burden. Obesity and diabetes have been strongly associated with NAFLD in different cities in Saudi Arabia. OBJECTIVES: Therefore, we aim to determine the prevalence rate of NAFLD and specific risk factors for NAFLD among patients of tertiary care hospital of Taif city. MATERIAL AND METHODS: We retrospectively analyzed the medical records of patients for two years, between Feb 2017 and Feb 2019, (n = 100) referred to the hepatology clinic at King Abdulaziz Specialist Hospital in Taif. The diagnosis of NAFLD was based on the radiology report for patients who were aged >20 years old. Other parameters including fasting blood glucose (FBG), platelets count, alanine transaminase (ALT), aspartate transaminase (AST) and total bilirubin were statistically analyzed. RESULTS: We found that 40% (P < 0.05) of all patients had NAFLD. The results revealed that a significantly high number of patients with NAFLD have high FBG levels (75%, P < 0.0001) and total bilirubin (P < 0.05). Meanwhile, platelet count was significantly reduced in patients with NAFLD (P < 0.05). CONCLUSION: NAFLD can be a serious health problem in the Taif region. In addition, high FBG is a significant specific risk factor for NAFLD. Health care providers should pay more attention to limiting the prevalence of NAFLD and its risk factors.
format Online
Article
Text
id pubmed-8381033
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-83810332021-08-30 Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study Alamri, Abdulhakeem S. Alhomrani, Majid Alsanie, Walaa F. Alghamdi, Ahmad Joman Alghamdi, Zaher M. Al-Subaie, Abdualmohsen A. Alharthi, Yasser A. Alqurashi, Hesham H. Asdaq, Syed Mohammed Basheeruddin Saudi J Biol Sci Original Article BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) in Saudi Arabia is predicted to exceed 30% by 2030. NAFLD leads to liver fibrosis, thus increasing morbidity and health care burden. Obesity and diabetes have been strongly associated with NAFLD in different cities in Saudi Arabia. OBJECTIVES: Therefore, we aim to determine the prevalence rate of NAFLD and specific risk factors for NAFLD among patients of tertiary care hospital of Taif city. MATERIAL AND METHODS: We retrospectively analyzed the medical records of patients for two years, between Feb 2017 and Feb 2019, (n = 100) referred to the hepatology clinic at King Abdulaziz Specialist Hospital in Taif. The diagnosis of NAFLD was based on the radiology report for patients who were aged >20 years old. Other parameters including fasting blood glucose (FBG), platelets count, alanine transaminase (ALT), aspartate transaminase (AST) and total bilirubin were statistically analyzed. RESULTS: We found that 40% (P < 0.05) of all patients had NAFLD. The results revealed that a significantly high number of patients with NAFLD have high FBG levels (75%, P < 0.0001) and total bilirubin (P < 0.05). Meanwhile, platelet count was significantly reduced in patients with NAFLD (P < 0.05). CONCLUSION: NAFLD can be a serious health problem in the Taif region. In addition, high FBG is a significant specific risk factor for NAFLD. Health care providers should pay more attention to limiting the prevalence of NAFLD and its risk factors. Elsevier 2021-09 2021-06-01 /pmc/articles/PMC8381033/ /pubmed/34466067 http://dx.doi.org/10.1016/j.sjbs.2021.05.063 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Alamri, Abdulhakeem S.
Alhomrani, Majid
Alsanie, Walaa F.
Alghamdi, Ahmad Joman
Alghamdi, Zaher M.
Al-Subaie, Abdualmohsen A.
Alharthi, Yasser A.
Alqurashi, Hesham H.
Asdaq, Syed Mohammed Basheeruddin
Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study
title Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study
title_full Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study
title_fullStr Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study
title_full_unstemmed Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study
title_short Prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of Taif, Saudi Arabia: A retrospective study
title_sort prevalence and predictors of non-alcoholic fatty liver disease in tertiary care hospital of taif, saudi arabia: a retrospective study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381033/
https://www.ncbi.nlm.nih.gov/pubmed/34466067
http://dx.doi.org/10.1016/j.sjbs.2021.05.063
work_keys_str_mv AT alamriabdulhakeems prevalenceandpredictorsofnonalcoholicfattyliverdiseaseintertiarycarehospitaloftaifsaudiarabiaaretrospectivestudy
AT alhomranimajid prevalenceandpredictorsofnonalcoholicfattyliverdiseaseintertiarycarehospitaloftaifsaudiarabiaaretrospectivestudy
AT alsaniewalaaf prevalenceandpredictorsofnonalcoholicfattyliverdiseaseintertiarycarehospitaloftaifsaudiarabiaaretrospectivestudy
AT alghamdiahmadjoman prevalenceandpredictorsofnonalcoholicfattyliverdiseaseintertiarycarehospitaloftaifsaudiarabiaaretrospectivestudy
AT alghamdizaherm prevalenceandpredictorsofnonalcoholicfattyliverdiseaseintertiarycarehospitaloftaifsaudiarabiaaretrospectivestudy
AT alsubaieabdualmohsena prevalenceandpredictorsofnonalcoholicfattyliverdiseaseintertiarycarehospitaloftaifsaudiarabiaaretrospectivestudy
AT alharthiyassera prevalenceandpredictorsofnonalcoholicfattyliverdiseaseintertiarycarehospitaloftaifsaudiarabiaaretrospectivestudy
AT alqurashiheshamh prevalenceandpredictorsofnonalcoholicfattyliverdiseaseintertiarycarehospitaloftaifsaudiarabiaaretrospectivestudy
AT asdaqsyedmohammedbasheeruddin prevalenceandpredictorsofnonalcoholicfattyliverdiseaseintertiarycarehospitaloftaifsaudiarabiaaretrospectivestudy