Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering

OBJECTIVE: Skeletal muscle is an attractive target for blood glucose-lowering pharmacological interventions. Oral dosing of small molecule direct pan-activators of AMPK that bind to the allosteric drug and metabolite (ADaM) site, lowers blood glucose through effects in skeletal muscle. The molecular...

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Detalles Bibliográficos
Autores principales: Jørgensen, Nicolas O., Kjøbsted, Rasmus, Larsen, Magnus R., Birk, Jesper B., Andersen, Nicoline R., Albuquerque, Bina, Schjerling, Peter, Miller, Russell, Carling, David, Pehmøller, Christian K., Wojtaszewski, Jørgen F.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381035/
https://www.ncbi.nlm.nih.gov/pubmed/34033941
http://dx.doi.org/10.1016/j.molmet.2021.101259

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