Insights Into the Structure-Function Relationships of Dimeric C3d Fragments

Cleavage of C3 to C3a and C3b plays a central role in the generation of complement-mediated defences. Although the thioester-mediated surface deposition of C3b has been well-studied, fluid phase dimers of C3 fragments remain largely unexplored. Here we show C3 cleavage results in the spontaneous for...

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Detalles Bibliográficos
Autores principales: Wahid, Ayla A., Dunphy, Rhys W., Macpherson, Alex, Gibson, Beth G., Kulik, Liudmila, Whale, Kevin, Back, Catherine, Hallam, Thomas M., Alkhawaja, Bayan, Martin, Rebecca L., Meschede, Ingrid, Laabei, Maisem, Lawson, Alastair D. G., Holers, V. Michael, Watts, Andrew G., Crennell, Susan J., Harris, Claire L., Marchbank, Kevin J., van den Elsen, Jean M. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381054/
https://www.ncbi.nlm.nih.gov/pubmed/34434196
http://dx.doi.org/10.3389/fimmu.2021.714055

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