The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease

Background: Patients with hematological disease are 15 times more likely to develop sepsis than the general population. The patient with hematological disease and, mainly, those undergoing hematopoietic stem cell transplantation (HSCT), develop a severe secondary humoral immunodeficiency, with low s...

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Detalles Bibliográficos
Autores principales: Fernandes, Pedro Amoedo, Russo, Flavia Tobaldini, da Silva, Lucas Augusto Monetta, Ramos, Lafayete Willian Ferreira, de Almeida Simões, Aline, Okada, Larissa Yukari, Cavalcante, Jamilla Neves, Ferreira Lopes, Maricy Almeida Viol, de Almeida Macedo, Maria Cristina Martins, da Silva, Roberto Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381108/
https://www.ncbi.nlm.nih.gov/pubmed/34466209
http://dx.doi.org/10.18502/ijhoscr.v15i2.6041
Descripción
Sumario:Background: Patients with hematological disease are 15 times more likely to develop sepsis than the general population. The patient with hematological disease and, mainly, those undergoing hematopoietic stem cell transplantation (HSCT), develop a severe secondary humoral immunodeficiency, with low serum levels of IgM, which may take more than a year to be restored. Materials andMethods: This is a retrospective, controlled and observational study that analyzed 51 patients with underlying hematological disease, who were diagnosed with sepsis or septic shock during the study period, to evaluate whether IgM-rich Ig replacement decreases the 30-day mortality. Results: Of the 51 patients, 35 patients received IgM-rich immunoglobulin (group A) and 16 (31%) received conventional therapy. Eleven (69%) patients in the control group were alive after 30 days compared to 11 (34%) patients in the intervention group, p= 0.013. Conclusion: There are no apparent benefits in the use of IgM-rich immunoglobulin in septic patients with hematological disease.

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