Successful Treatment of Antifungal Combination Therapy with Inhaled Liposomal Amphotericin B and Oral Voriconazole for Intractable Chronic Progressive Pulmonary Aspergillosis

We experienced a case of the successful treatment of intractable pulmonary aspergillosis with inhaled liposomal amphotericin B (L-AMB) and oral voriconazole (VRCZ). A 52-year-old man was admitted to our hospital with a fever. Chest computed tomography (CT) revealed an infiltrative shadow. Two separa...

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Autores principales: Hamada, Noboru, Ishiga, Mitsunori, Tanaka, Suzuka, Ooue, Yasuhiro, Itano, Junko, Tanaka, Hisaaki, Yuzurio, Shota, Horiuchi, Takeshi, Suwaki, Toshimitsu, Kimura, Goro, Tanimoto, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381164/
https://www.ncbi.nlm.nih.gov/pubmed/33678738
http://dx.doi.org/10.2169/internalmedicine.6305-20
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author Hamada, Noboru
Ishiga, Mitsunori
Tanaka, Suzuka
Ooue, Yasuhiro
Itano, Junko
Tanaka, Hisaaki
Yuzurio, Shota
Horiuchi, Takeshi
Suwaki, Toshimitsu
Kimura, Goro
Tanimoto, Yasushi
author_facet Hamada, Noboru
Ishiga, Mitsunori
Tanaka, Suzuka
Ooue, Yasuhiro
Itano, Junko
Tanaka, Hisaaki
Yuzurio, Shota
Horiuchi, Takeshi
Suwaki, Toshimitsu
Kimura, Goro
Tanimoto, Yasushi
author_sort Hamada, Noboru
collection PubMed
description We experienced a case of the successful treatment of intractable pulmonary aspergillosis with inhaled liposomal amphotericin B (L-AMB) and oral voriconazole (VRCZ). A 52-year-old man was admitted to our hospital with a fever. Chest computed tomography (CT) revealed an infiltrative shadow. Two separate sputum cultures detected Aspergillus niger. Although we treated the patient with single and combined antifungal agents, the infiltrative shadow worsened. After obtaining sufficient informed consent from the patient, we switched him to an inhaled L-AMB. The infiltrative shadow subsequently improved. The patient has remained well for one year without exacerbation. We herein report the usefulness of inhaled L-AMB and oral VRCZ.
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spelling pubmed-83811642021-08-30 Successful Treatment of Antifungal Combination Therapy with Inhaled Liposomal Amphotericin B and Oral Voriconazole for Intractable Chronic Progressive Pulmonary Aspergillosis Hamada, Noboru Ishiga, Mitsunori Tanaka, Suzuka Ooue, Yasuhiro Itano, Junko Tanaka, Hisaaki Yuzurio, Shota Horiuchi, Takeshi Suwaki, Toshimitsu Kimura, Goro Tanimoto, Yasushi Intern Med Case Report We experienced a case of the successful treatment of intractable pulmonary aspergillosis with inhaled liposomal amphotericin B (L-AMB) and oral voriconazole (VRCZ). A 52-year-old man was admitted to our hospital with a fever. Chest computed tomography (CT) revealed an infiltrative shadow. Two separate sputum cultures detected Aspergillus niger. Although we treated the patient with single and combined antifungal agents, the infiltrative shadow worsened. After obtaining sufficient informed consent from the patient, we switched him to an inhaled L-AMB. The infiltrative shadow subsequently improved. The patient has remained well for one year without exacerbation. We herein report the usefulness of inhaled L-AMB and oral VRCZ. The Japanese Society of Internal Medicine 2021-03-08 2021-08-01 /pmc/articles/PMC8381164/ /pubmed/33678738 http://dx.doi.org/10.2169/internalmedicine.6305-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hamada, Noboru
Ishiga, Mitsunori
Tanaka, Suzuka
Ooue, Yasuhiro
Itano, Junko
Tanaka, Hisaaki
Yuzurio, Shota
Horiuchi, Takeshi
Suwaki, Toshimitsu
Kimura, Goro
Tanimoto, Yasushi
Successful Treatment of Antifungal Combination Therapy with Inhaled Liposomal Amphotericin B and Oral Voriconazole for Intractable Chronic Progressive Pulmonary Aspergillosis
title Successful Treatment of Antifungal Combination Therapy with Inhaled Liposomal Amphotericin B and Oral Voriconazole for Intractable Chronic Progressive Pulmonary Aspergillosis
title_full Successful Treatment of Antifungal Combination Therapy with Inhaled Liposomal Amphotericin B and Oral Voriconazole for Intractable Chronic Progressive Pulmonary Aspergillosis
title_fullStr Successful Treatment of Antifungal Combination Therapy with Inhaled Liposomal Amphotericin B and Oral Voriconazole for Intractable Chronic Progressive Pulmonary Aspergillosis
title_full_unstemmed Successful Treatment of Antifungal Combination Therapy with Inhaled Liposomal Amphotericin B and Oral Voriconazole for Intractable Chronic Progressive Pulmonary Aspergillosis
title_short Successful Treatment of Antifungal Combination Therapy with Inhaled Liposomal Amphotericin B and Oral Voriconazole for Intractable Chronic Progressive Pulmonary Aspergillosis
title_sort successful treatment of antifungal combination therapy with inhaled liposomal amphotericin b and oral voriconazole for intractable chronic progressive pulmonary aspergillosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381164/
https://www.ncbi.nlm.nih.gov/pubmed/33678738
http://dx.doi.org/10.2169/internalmedicine.6305-20
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