Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus

Age-related Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disorder (LPD) occurs in elderly patients without immunodeficiency. An 81-year-old woman without any known immunodeficiency was examined for fever, rash, arthritis, thrombocytopenia, pleural and pericardial effusions, lymphaden...

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Autores principales: Kadoba, Keiichiro, Nishimura, Keisuke, Uchino, Kaori, Waki, Daisuke, Murabe, Hiroyuki, Yokota, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381174/
https://www.ncbi.nlm.nih.gov/pubmed/33583902
http://dx.doi.org/10.2169/internalmedicine.6702-20
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author Kadoba, Keiichiro
Nishimura, Keisuke
Uchino, Kaori
Waki, Daisuke
Murabe, Hiroyuki
Yokota, Toshihiko
author_facet Kadoba, Keiichiro
Nishimura, Keisuke
Uchino, Kaori
Waki, Daisuke
Murabe, Hiroyuki
Yokota, Toshihiko
author_sort Kadoba, Keiichiro
collection PubMed
description Age-related Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disorder (LPD) occurs in elderly patients without immunodeficiency. An 81-year-old woman without any known immunodeficiency was examined for fever, rash, arthritis, thrombocytopenia, pleural and pericardial effusions, lymphadenopathy, and positive autoantibodies, which satisfied the classification criteria for systemic lupus erythematosus (SLE). However, a lymph node biopsy revealed EBV-LPD, and she was diagnosed with age-related EBV-LPD. In young individuals, EBV infection is a major differential diagnosis of SLE, but to our knowledge, this is the first reported case of age-related EBV-LPD mimicking SLE. We should therefore consider EBV-related disorders in the differential diagnosis of SLE even in elderly individuals.
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spelling pubmed-83811742021-08-30 Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus Kadoba, Keiichiro Nishimura, Keisuke Uchino, Kaori Waki, Daisuke Murabe, Hiroyuki Yokota, Toshihiko Intern Med Case Report Age-related Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disorder (LPD) occurs in elderly patients without immunodeficiency. An 81-year-old woman without any known immunodeficiency was examined for fever, rash, arthritis, thrombocytopenia, pleural and pericardial effusions, lymphadenopathy, and positive autoantibodies, which satisfied the classification criteria for systemic lupus erythematosus (SLE). However, a lymph node biopsy revealed EBV-LPD, and she was diagnosed with age-related EBV-LPD. In young individuals, EBV infection is a major differential diagnosis of SLE, but to our knowledge, this is the first reported case of age-related EBV-LPD mimicking SLE. We should therefore consider EBV-related disorders in the differential diagnosis of SLE even in elderly individuals. The Japanese Society of Internal Medicine 2021-02-15 2021-08-01 /pmc/articles/PMC8381174/ /pubmed/33583902 http://dx.doi.org/10.2169/internalmedicine.6702-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kadoba, Keiichiro
Nishimura, Keisuke
Uchino, Kaori
Waki, Daisuke
Murabe, Hiroyuki
Yokota, Toshihiko
Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus
title Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus
title_full Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus
title_fullStr Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus
title_full_unstemmed Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus
title_short Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus
title_sort age-related epstein-barr virus-associated lymphoproliferative disorder masquerading as systemic lupus erythematosus
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381174/
https://www.ncbi.nlm.nih.gov/pubmed/33583902
http://dx.doi.org/10.2169/internalmedicine.6702-20
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