Acute Liver Injury Due to T-cell Infiltration into the Liver as an Initial Clinical Finding of Adult T-cell Leukemia/Lymphoma

Acute liver injury (ALI) has been rarely reported as a clinical finding of adult T-cell leukemia/lymphoma (ATLL). A 74-year-old Japanese female patient who was histologically diagnosed as having autoimmune hepatitis (AIH) one year earlier, showed elevations in her aminotransferase and total bilirubi...

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Autores principales: Kakisaka, Keisuke, Suzuki, Yuji, Kowata, Shugo, Ito, Shigeki, Takikawa, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381176/
https://www.ncbi.nlm.nih.gov/pubmed/34334592
http://dx.doi.org/10.2169/internalmedicine.6793-20
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author Kakisaka, Keisuke
Suzuki, Yuji
Kowata, Shugo
Ito, Shigeki
Takikawa, Yasuhiro
author_facet Kakisaka, Keisuke
Suzuki, Yuji
Kowata, Shugo
Ito, Shigeki
Takikawa, Yasuhiro
author_sort Kakisaka, Keisuke
collection PubMed
description Acute liver injury (ALI) has been rarely reported as a clinical finding of adult T-cell leukemia/lymphoma (ATLL). A 74-year-old Japanese female patient who was histologically diagnosed as having autoimmune hepatitis (AIH) one year earlier, showed elevations in her aminotransferase and total bilirubin levels, and this was considered to be an exacerbation of AIH. Liver biopsy revealed interface hepatitis. Because atypical lymphocytes and human T-cell leukemia virus 1 immunoglobulin G antibody were positive, the patient was diagnosed to have ATLL. The biopsy revealed CD4+ and CD8+, but not CD20+ lymphocytes. Thus, the ALI in the patient was due to T-cell infiltration into the liver, and not due to an exacerbation of AIH.
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spelling pubmed-83811762021-08-30 Acute Liver Injury Due to T-cell Infiltration into the Liver as an Initial Clinical Finding of Adult T-cell Leukemia/Lymphoma Kakisaka, Keisuke Suzuki, Yuji Kowata, Shugo Ito, Shigeki Takikawa, Yasuhiro Intern Med Case Report Acute liver injury (ALI) has been rarely reported as a clinical finding of adult T-cell leukemia/lymphoma (ATLL). A 74-year-old Japanese female patient who was histologically diagnosed as having autoimmune hepatitis (AIH) one year earlier, showed elevations in her aminotransferase and total bilirubin levels, and this was considered to be an exacerbation of AIH. Liver biopsy revealed interface hepatitis. Because atypical lymphocytes and human T-cell leukemia virus 1 immunoglobulin G antibody were positive, the patient was diagnosed to have ATLL. The biopsy revealed CD4+ and CD8+, but not CD20+ lymphocytes. Thus, the ALI in the patient was due to T-cell infiltration into the liver, and not due to an exacerbation of AIH. The Japanese Society of Internal Medicine 2021-08-01 2021-08-01 /pmc/articles/PMC8381176/ /pubmed/34334592 http://dx.doi.org/10.2169/internalmedicine.6793-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kakisaka, Keisuke
Suzuki, Yuji
Kowata, Shugo
Ito, Shigeki
Takikawa, Yasuhiro
Acute Liver Injury Due to T-cell Infiltration into the Liver as an Initial Clinical Finding of Adult T-cell Leukemia/Lymphoma
title Acute Liver Injury Due to T-cell Infiltration into the Liver as an Initial Clinical Finding of Adult T-cell Leukemia/Lymphoma
title_full Acute Liver Injury Due to T-cell Infiltration into the Liver as an Initial Clinical Finding of Adult T-cell Leukemia/Lymphoma
title_fullStr Acute Liver Injury Due to T-cell Infiltration into the Liver as an Initial Clinical Finding of Adult T-cell Leukemia/Lymphoma
title_full_unstemmed Acute Liver Injury Due to T-cell Infiltration into the Liver as an Initial Clinical Finding of Adult T-cell Leukemia/Lymphoma
title_short Acute Liver Injury Due to T-cell Infiltration into the Liver as an Initial Clinical Finding of Adult T-cell Leukemia/Lymphoma
title_sort acute liver injury due to t-cell infiltration into the liver as an initial clinical finding of adult t-cell leukemia/lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381176/
https://www.ncbi.nlm.nih.gov/pubmed/34334592
http://dx.doi.org/10.2169/internalmedicine.6793-20
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