Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus

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To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putati...

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Detalles Bibliográficos
Autores principales: Kasela, Silva, Daniloski, Zharko, Bollepalli, Sailalitha, Jordan, Tristan X., tenOever, Benjamin R., Sanjana, Neville E., Lappalainen, Tuuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381345/
https://www.ncbi.nlm.nih.gov/pubmed/34425859
http://dx.doi.org/10.1186/s13059-021-02454-4
Descripción
Sumario:To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that modulate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-021-02454-4.

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