Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus

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To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putati...

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Autores principales: Kasela, Silva, Daniloski, Zharko, Bollepalli, Sailalitha, Jordan, Tristan X., tenOever, Benjamin R., Sanjana, Neville E., Lappalainen, Tuuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381345/
https://www.ncbi.nlm.nih.gov/pubmed/34425859
http://dx.doi.org/10.1186/s13059-021-02454-4
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author Kasela, Silva
Daniloski, Zharko
Bollepalli, Sailalitha
Jordan, Tristan X.
tenOever, Benjamin R.
Sanjana, Neville E.
Lappalainen, Tuuli
author_facet Kasela, Silva
Daniloski, Zharko
Bollepalli, Sailalitha
Jordan, Tristan X.
tenOever, Benjamin R.
Sanjana, Neville E.
Lappalainen, Tuuli
author_sort Kasela, Silva
collection PubMed
description To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that modulate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-021-02454-4.
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spelling pubmed-83813452021-08-23 Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus Kasela, Silva Daniloski, Zharko Bollepalli, Sailalitha Jordan, Tristan X. tenOever, Benjamin R. Sanjana, Neville E. Lappalainen, Tuuli Genome Biol Short Report To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that modulate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-021-02454-4. BioMed Central 2021-08-23 /pmc/articles/PMC8381345/ /pubmed/34425859 http://dx.doi.org/10.1186/s13059-021-02454-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Kasela, Silva
Daniloski, Zharko
Bollepalli, Sailalitha
Jordan, Tristan X.
tenOever, Benjamin R.
Sanjana, Neville E.
Lappalainen, Tuuli
Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus
title Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus
title_full Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus
title_fullStr Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus
title_full_unstemmed Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus
title_short Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus
title_sort integrative approach identifies slc6a20 and cxcr6 as putative causal genes for the covid-19 gwas signal in the 3p21.31 locus
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381345/
https://www.ncbi.nlm.nih.gov/pubmed/34425859
http://dx.doi.org/10.1186/s13059-021-02454-4
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