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Bone sarcoma: success through interdisciplinary collaboration

PURPOSE: Osteosarcoma and Ewing sarcoma are the most frequent malignant bone tumours of childhood and adolescence. This review summarizes the oncologist’s view of these diseases and their treatment. METHODS: A non-systematic literature review was performed, the personal impressions and experience of...

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Autores principales: Hecker-Nolting, Stefanie, Maia Ferreira, Ana, Bielack, Stefan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Editorial Society of Bone & Joint Surgery 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381399/
https://www.ncbi.nlm.nih.gov/pubmed/34476022
http://dx.doi.org/10.1302/1863-2548.15.210122
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author Hecker-Nolting, Stefanie
Maia Ferreira, Ana
Bielack, Stefan S.
author_facet Hecker-Nolting, Stefanie
Maia Ferreira, Ana
Bielack, Stefan S.
author_sort Hecker-Nolting, Stefanie
collection PubMed
description PURPOSE: Osteosarcoma and Ewing sarcoma are the most frequent malignant bone tumours of childhood and adolescence. This review summarizes the oncologist’s view of these diseases and their treatment. METHODS: A non-systematic literature review was performed, the personal impressions and experience of the authors is described. RESULTS: Local therapy and chemotherapy, each on their own, will not cure patients with malignant bone sarcomas. Together, they present a highly efficacious combination. While the most effective drugs were defined decades ago, progress since then has been limited. It is hoped that substances shown to be active in relapsed disease will be forwarded into even more efficacious frontline treatments. Good palliative therapy is necessary when cure is no longer an option. CONCLUSION: Close interdisciplinary collaboration is the key to successful treatment of bone sarcomas in paediatric patients.
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spelling pubmed-83813992021-09-01 Bone sarcoma: success through interdisciplinary collaboration Hecker-Nolting, Stefanie Maia Ferreira, Ana Bielack, Stefan S. J Child Orthop Current Concepts Review PURPOSE: Osteosarcoma and Ewing sarcoma are the most frequent malignant bone tumours of childhood and adolescence. This review summarizes the oncologist’s view of these diseases and their treatment. METHODS: A non-systematic literature review was performed, the personal impressions and experience of the authors is described. RESULTS: Local therapy and chemotherapy, each on their own, will not cure patients with malignant bone sarcomas. Together, they present a highly efficacious combination. While the most effective drugs were defined decades ago, progress since then has been limited. It is hoped that substances shown to be active in relapsed disease will be forwarded into even more efficacious frontline treatments. Good palliative therapy is necessary when cure is no longer an option. CONCLUSION: Close interdisciplinary collaboration is the key to successful treatment of bone sarcomas in paediatric patients. The British Editorial Society of Bone & Joint Surgery 2021-08-20 /pmc/articles/PMC8381399/ /pubmed/34476022 http://dx.doi.org/10.1302/1863-2548.15.210122 Text en Copyright © 2021, The author(s) https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed.
spellingShingle Current Concepts Review
Hecker-Nolting, Stefanie
Maia Ferreira, Ana
Bielack, Stefan S.
Bone sarcoma: success through interdisciplinary collaboration
title Bone sarcoma: success through interdisciplinary collaboration
title_full Bone sarcoma: success through interdisciplinary collaboration
title_fullStr Bone sarcoma: success through interdisciplinary collaboration
title_full_unstemmed Bone sarcoma: success through interdisciplinary collaboration
title_short Bone sarcoma: success through interdisciplinary collaboration
title_sort bone sarcoma: success through interdisciplinary collaboration
topic Current Concepts Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381399/
https://www.ncbi.nlm.nih.gov/pubmed/34476022
http://dx.doi.org/10.1302/1863-2548.15.210122
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