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Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study

There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in...

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Autores principales: Berberian, Griselda, Bologna, Rosa, Pérez, María Guadalupe, Mangano, Andrea, Costa, Marina, Calligaris, Silvana, Morales, María Alejandra, Rugilo, Carlos, Ruiz-Burga, Elisa, Thorne, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381406/
https://www.ncbi.nlm.nih.gov/pubmed/34435083
http://dx.doi.org/10.1177/2333794X211040968
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author Berberian, Griselda
Bologna, Rosa
Pérez, María Guadalupe
Mangano, Andrea
Costa, Marina
Calligaris, Silvana
Morales, María Alejandra
Rugilo, Carlos
Ruiz-Burga, Elisa
Thorne, Claire
author_facet Berberian, Griselda
Bologna, Rosa
Pérez, María Guadalupe
Mangano, Andrea
Costa, Marina
Calligaris, Silvana
Morales, María Alejandra
Rugilo, Carlos
Ruiz-Burga, Elisa
Thorne, Claire
author_sort Berberian, Griselda
collection PubMed
description There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non-infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%).
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spelling pubmed-83814062021-08-24 Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study Berberian, Griselda Bologna, Rosa Pérez, María Guadalupe Mangano, Andrea Costa, Marina Calligaris, Silvana Morales, María Alejandra Rugilo, Carlos Ruiz-Burga, Elisa Thorne, Claire Glob Pediatr Health Original Research Article There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non-infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%). SAGE Publications 2021-08-20 /pmc/articles/PMC8381406/ /pubmed/34435083 http://dx.doi.org/10.1177/2333794X211040968 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Berberian, Griselda
Bologna, Rosa
Pérez, María Guadalupe
Mangano, Andrea
Costa, Marina
Calligaris, Silvana
Morales, María Alejandra
Rugilo, Carlos
Ruiz-Burga, Elisa
Thorne, Claire
Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
title Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
title_full Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
title_fullStr Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
title_full_unstemmed Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
title_short Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
title_sort causes of microcephaly in the zika era in argentina: a retrospective study
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381406/
https://www.ncbi.nlm.nih.gov/pubmed/34435083
http://dx.doi.org/10.1177/2333794X211040968
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