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Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381406/ https://www.ncbi.nlm.nih.gov/pubmed/34435083 http://dx.doi.org/10.1177/2333794X211040968 |
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author | Berberian, Griselda Bologna, Rosa Pérez, María Guadalupe Mangano, Andrea Costa, Marina Calligaris, Silvana Morales, María Alejandra Rugilo, Carlos Ruiz-Burga, Elisa Thorne, Claire |
author_facet | Berberian, Griselda Bologna, Rosa Pérez, María Guadalupe Mangano, Andrea Costa, Marina Calligaris, Silvana Morales, María Alejandra Rugilo, Carlos Ruiz-Burga, Elisa Thorne, Claire |
author_sort | Berberian, Griselda |
collection | PubMed |
description | There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non-infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%). |
format | Online Article Text |
id | pubmed-8381406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-83814062021-08-24 Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study Berberian, Griselda Bologna, Rosa Pérez, María Guadalupe Mangano, Andrea Costa, Marina Calligaris, Silvana Morales, María Alejandra Rugilo, Carlos Ruiz-Burga, Elisa Thorne, Claire Glob Pediatr Health Original Research Article There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non-infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%). SAGE Publications 2021-08-20 /pmc/articles/PMC8381406/ /pubmed/34435083 http://dx.doi.org/10.1177/2333794X211040968 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Berberian, Griselda Bologna, Rosa Pérez, María Guadalupe Mangano, Andrea Costa, Marina Calligaris, Silvana Morales, María Alejandra Rugilo, Carlos Ruiz-Burga, Elisa Thorne, Claire Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study |
title | Causes of Microcephaly in the Zika Era in Argentina: A Retrospective
Study |
title_full | Causes of Microcephaly in the Zika Era in Argentina: A Retrospective
Study |
title_fullStr | Causes of Microcephaly in the Zika Era in Argentina: A Retrospective
Study |
title_full_unstemmed | Causes of Microcephaly in the Zika Era in Argentina: A Retrospective
Study |
title_short | Causes of Microcephaly in the Zika Era in Argentina: A Retrospective
Study |
title_sort | causes of microcephaly in the zika era in argentina: a retrospective
study |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381406/ https://www.ncbi.nlm.nih.gov/pubmed/34435083 http://dx.doi.org/10.1177/2333794X211040968 |
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