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Burden of Seasonal Influenza A and B in Panama from 2011 to 2017: An Observational Retrospective Database Study
INTRODUCTION: Influenza A and B viruses constantly evolve and cause seasonal epidemics and sporadic outbreaks. Therefore, epidemiological surveillance is critical for monitoring their circulation pattern. Trivalent and quadrivalent vaccine formulations are available in Panama (until and since 2016,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381717/ https://www.ncbi.nlm.nih.gov/pubmed/34424506 http://dx.doi.org/10.1007/s40121-021-00501-y |
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author | Pascale, Juan Miguel Franco, Danilo Devadiga, Raghavendra DeAntonio, Rodrigo Dominguez-Salazar, Elidia Lourdes dos Santos, Gael Juliao, Patricia |
author_facet | Pascale, Juan Miguel Franco, Danilo Devadiga, Raghavendra DeAntonio, Rodrigo Dominguez-Salazar, Elidia Lourdes dos Santos, Gael Juliao, Patricia |
author_sort | Pascale, Juan Miguel |
collection | PubMed |
description | INTRODUCTION: Influenza A and B viruses constantly evolve and cause seasonal epidemics and sporadic outbreaks. Therefore, epidemiological surveillance is critical for monitoring their circulation pattern. Trivalent and quadrivalent vaccine formulations are available in Panama (until and since 2016, respectively). Herein, we analysed influenza A and B epidemiological patterns in Panama. METHODS: This was a retrospective descriptive analysis of all laboratory-confirmed influenza nasopharyngeal samples recorded between 2011 and 2017 in the nationwide surveillance database of Gorgas Memorial Institute for Health Studies. The analysis involved data relative to demographic information, virus type, subtype and lineage, geographic region, treatment and outcomes. The percentage level of mismatch between circulating and vaccine-recommended B lineage was assessed for each May–October influenza season. RESULTS: Among 1839 influenza cases, 79.6% were type A and 20.4% were type B. Most of them were observed in Panama City (54.7%) followed by the West (23.2%) and Central (16.7%) regions; across all regions, influenza A and B cases were distributed in a 4:1 ratio. Overall, approximately half were hospitalized (52.0% for type A; 45.5% for type B) and 11 (0.6%) died. Treatment, usually antimicrobial, was administered in 15.1% of cases. Children less than 2 years old were the most affected by this disease. Influenza type A circulated every year, while influenza B only circulated in 2012, 2014 and 2017. In the 2012 May–October influenza B season, the predominant lineage was B/Victoria and a switch to B/Yamagata was observed in 2014. Both lineages co-circulated in 2017, leading to a 38.9% B-lineage-level vaccine mismatch. CONCLUSION: Influenza A was predominant among all ages and children less than 2 years and inhabitants of Panama City reported the highest circulation rate. In 2017, co-circulation of both B lineages led to a vaccine mismatch. Continuous monitoring of seasonal influenza is critical to establish immunization recommendations. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40121-021-00501-y. |
format | Online Article Text |
id | pubmed-8381717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-83817172021-08-23 Burden of Seasonal Influenza A and B in Panama from 2011 to 2017: An Observational Retrospective Database Study Pascale, Juan Miguel Franco, Danilo Devadiga, Raghavendra DeAntonio, Rodrigo Dominguez-Salazar, Elidia Lourdes dos Santos, Gael Juliao, Patricia Infect Dis Ther Original Research INTRODUCTION: Influenza A and B viruses constantly evolve and cause seasonal epidemics and sporadic outbreaks. Therefore, epidemiological surveillance is critical for monitoring their circulation pattern. Trivalent and quadrivalent vaccine formulations are available in Panama (until and since 2016, respectively). Herein, we analysed influenza A and B epidemiological patterns in Panama. METHODS: This was a retrospective descriptive analysis of all laboratory-confirmed influenza nasopharyngeal samples recorded between 2011 and 2017 in the nationwide surveillance database of Gorgas Memorial Institute for Health Studies. The analysis involved data relative to demographic information, virus type, subtype and lineage, geographic region, treatment and outcomes. The percentage level of mismatch between circulating and vaccine-recommended B lineage was assessed for each May–October influenza season. RESULTS: Among 1839 influenza cases, 79.6% were type A and 20.4% were type B. Most of them were observed in Panama City (54.7%) followed by the West (23.2%) and Central (16.7%) regions; across all regions, influenza A and B cases were distributed in a 4:1 ratio. Overall, approximately half were hospitalized (52.0% for type A; 45.5% for type B) and 11 (0.6%) died. Treatment, usually antimicrobial, was administered in 15.1% of cases. Children less than 2 years old were the most affected by this disease. Influenza type A circulated every year, while influenza B only circulated in 2012, 2014 and 2017. In the 2012 May–October influenza B season, the predominant lineage was B/Victoria and a switch to B/Yamagata was observed in 2014. Both lineages co-circulated in 2017, leading to a 38.9% B-lineage-level vaccine mismatch. CONCLUSION: Influenza A was predominant among all ages and children less than 2 years and inhabitants of Panama City reported the highest circulation rate. In 2017, co-circulation of both B lineages led to a vaccine mismatch. Continuous monitoring of seasonal influenza is critical to establish immunization recommendations. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40121-021-00501-y. Springer Healthcare 2021-08-23 2021-12 /pmc/articles/PMC8381717/ /pubmed/34424506 http://dx.doi.org/10.1007/s40121-021-00501-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Pascale, Juan Miguel Franco, Danilo Devadiga, Raghavendra DeAntonio, Rodrigo Dominguez-Salazar, Elidia Lourdes dos Santos, Gael Juliao, Patricia Burden of Seasonal Influenza A and B in Panama from 2011 to 2017: An Observational Retrospective Database Study |
title | Burden of Seasonal Influenza A and B in Panama from 2011 to 2017: An Observational Retrospective Database Study |
title_full | Burden of Seasonal Influenza A and B in Panama from 2011 to 2017: An Observational Retrospective Database Study |
title_fullStr | Burden of Seasonal Influenza A and B in Panama from 2011 to 2017: An Observational Retrospective Database Study |
title_full_unstemmed | Burden of Seasonal Influenza A and B in Panama from 2011 to 2017: An Observational Retrospective Database Study |
title_short | Burden of Seasonal Influenza A and B in Panama from 2011 to 2017: An Observational Retrospective Database Study |
title_sort | burden of seasonal influenza a and b in panama from 2011 to 2017: an observational retrospective database study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381717/ https://www.ncbi.nlm.nih.gov/pubmed/34424506 http://dx.doi.org/10.1007/s40121-021-00501-y |
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