Cargando…

Metabolomics Reveals the Mechanisms for the Pulmonary Toxicity of Siegesbeckia orientalis L. and the Toxicity-Reducing Effect of Processing

Siegesbeckia orientalis L. (SO) is a commonly used Chinese medicinal herb. It has long been used as a remedy in traditional Chinese medicine (TCM) for symptoms that resemble inflammatory joint disorders. However, it is slightly toxic. According to the TCM theory, processing can reduce the toxicity o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Ting, Liu, Linsheng, Zhang, Mi, Qiao, Zhiping, Zhao, Tingxiu, Su, Junfang, Cao, Gang, Su, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381750/ https://www.ncbi.nlm.nih.gov/pubmed/34434104 http://dx.doi.org/10.3389/fphar.2021.630319

Ejemplares similares

The complete chloroplast genome sequence of the medicinal plant Siegesbeckia orientalis L., the first in the genus Siegesbeckia
por: Liu, Jingting, et al.
Publicado: (2019)

Activation and tolerance of Siegesbeckia Orientalis L. rhizosphere to Cd stress
por: Xie, Jianyu, et al.
Publicado: (2023)

Siegesbeckia Orientalis L. Extract Attenuates Postoperative Cognitive Dysfunction, Systemic Inflammation, and Neuroinflammation
por: Chu, John Man Tak, et al.
Publicado: (2018)

Anti-Inflammatory Effects of Siegesbeckia orientalis Ethanol Extract in In Vitro and In Vivo Models
por: Hong, Yong-Han, et al.
Publicado: (2014)

Twenty-four-week oral dosing toxicities of Herba Siegesbeckiae in rats
por: Wu, Jia-Ying, et al.
Publicado: (2020)

Toxicity of Tetradium ruticarpum: Subacute Toxicity Assessment and Metabolomic Identification of Relevant Biomarkers
por: Shan, Qiyuan, et al.
Publicado: (2022)

Siegesbeckia orientalis Extract Inhibits TGFβ1-Induced Migration and Invasion of Endometrial Cancer Cells
por: Chang, Chi-Chang, et al.
Publicado: (2016)

Anti-Proliferative Effects of Siegesbeckia orientalis Ethanol Extract on Human Endometrial RL-95 Cancer Cells
por: Chang, Chi-Chang, et al.
Publicado: (2014)

Inhibitory Effects of Siegesbeckia orientalis Extracts on Advanced Glycation End Product Formation and Key Enzymes Related to Metabolic Syndrome
por: Hung, Wei-Chin, et al.
Publicado: (2017)

Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content
por: Nguyen, Thuy Duong, et al.
Publicado: (2017)

Comparison of the chemical profiles and inflammatory mediator-inhibitory effects of three Siegesbeckia herbs used as Herba Siegesbeckiae (Xixiancao)
por: Guo, Hui, et al.
Publicado: (2018)

Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity
por: Shan, Qi-yuan, et al.
Publicado: (2020)

Metabolomics reveals the mechanisms for the cardiotoxicity of Pinelliae Rhizoma and the toxicity-reducing effect of processing
por: Su, Tao, et al.
Publicado: (2016)

Suppressive Effects of Siegesbeckia orientalis Ethanolic Extract on Proliferation and Migration of Hepatocellular Carcinoma Cells through Promoting Oxidative Stress, Apoptosis and Inflammatory Responses
por: Chen, Tzu-Hua, et al.
Publicado: (2022)

Antiperiodontitis Effects of Siegesbeckia glabrescens In Vitro
por: Bellere, Arce Defeo, et al.
Publicado: (2023)

Comparative Analysis of Chemical Composition, Anti-Inflammatory Activity and Antitumor Activity in Essential Oils from Siegesbeckia orientalis, S. glabrescens and S. pubescens with an ITS Sequence Analysis
por: Gao, Xiaoxu, et al.
Publicado: (2018)

New Cytotoxic Sesquiterpenoids from Siegesbeckia glabrescens
por: Wu, Qian, et al.
Publicado: (2015)

Editorial: Therapeutic and Diagnosis Target Discovery Based on Metabolomics
por: Liu, Linsheng
Publicado: (2022)

Integrative Metabolomics, Proteomics and Transcriptomics Analysis Reveals Liver Toxicity of Mesoporous Silica Nanoparticles
por: Li, Jing, et al.
Publicado: (2022)

Dissecting Target Toxic Tissue and Tissue Specific Responses of Irinotecan in Rats Using Metabolomics Approach
por: Yao, Yiran, et al.
Publicado: (2017)

Gut Microbiota Combined With Metabolomics Reveals the Repeated Dose Oral Toxicity of β-Cyclodextrin in Mice
por: Lv, Shuangyu, et al.
Publicado: (2021)

Metabolic Profiling Analysis of the Alleviation Effect of Treatment with Baicalin on Cinnabar Induced Toxicity in Rats Urine and Serum
por: Su, Guangyue, et al.
Publicado: (2017)

A Novel Antibacterial Compound from Siegesbeckia glabrescens
por: Kim, Young-Soo, et al.
Publicado: (2012)

Screening of Biomarkers and Toxicity Mechanisms of Rifampicin-Induced Liver Injury Based on Targeted Bile Acid Metabolomics
por: Deng, Yang, et al.
Publicado: (2022)

Toxic Constituents Index: A Toxicity-Calibrated Quantitative Evaluation Approach for the Precise Toxicity Prediction of the Hypertoxic Phytomedicine—Aconite
por: Zhang, Ding-kun, et al.
Publicado: (2016)

Quantitative Evaluation of the Compatibility Effects of Huangqin Decoction on the Treatment of Irinotecan-Induced Gastrointestinal Toxicity Using Untargeted Metabolomics
por: Cui, Dong-Ni, et al.
Publicado: (2017)

Dose-Effect/Toxicity of Bupleuri Radix on Chronic Unpredictable Mild Stress and Normal Rats Based on Liver Metabolomics
por: Wang, Peng, et al.
Publicado: (2021)

Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells
por: Chhour, Monivan, et al.
Publicado: (2021)

Coadministration of bedaquiline and pyrifazimine reduce exposure to toxic metabolite N-desmethyl bedaquiline
por: Ding, Yangming, et al.
Publicado: (2023)

Potential role of gut microbes in the efficacy and toxicity of immune checkpoints inhibitors
por: Ma, Jingxin, et al.
Publicado: (2023)

Protective Effects of Magnesium Glycyrrhizinate on Methotrexate-Induced Hepatotoxicity and Intestinal Toxicity May Be by Reducing COX-2
por: Cao, Yuzhu, et al.
Publicado: (2019)

Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia
por: Cao, Minyuan, et al.
Publicado: (2020)

Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis
por: Han, Lifeng, et al.
Publicado: (2019)

Pulmonary Toxicity and the Pathophysiology of Electronic Cigarette, or Vaping Product, Use Associated Lung Injury
por: Chand, Hitendra S., et al.
Publicado: (2020)

Metabolic Activation of the Toxic Natural Products From Herbal and Dietary Supplements Leading to Toxicities
por: Wang, Yi-Kun, et al.
Publicado: (2021)

Alisma orientalis Beverage Treats Atherosclerosis by Regulating Gut Microbiota in ApoE(-/-) Mice
por: Zhu, Boran, et al.
Publicado: (2020)

Nano-Neurotheranostics: Impact of Nanoparticles on Neural Dysfunctions and Strategies to Reduce Toxicity for Improved Efficacy
por: Vinod, Chiluka, et al.
Publicado: (2021)

Impact of implementing a vancomycin protocol to reduce kidney toxicity: A comparative study
por: Baiocco, Graziella Gasparotto, et al.
Publicado: (2023)

The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review
por: Kuang, Xiaolan, et al.
Publicado: (2022)

Predictive Toxicity: Grand Challenges
por: Pelkonen, Olavi
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_rt9ofcbsegjubd12s8em0gn473