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Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide

BACKGROUND AND AIMS: Fetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes. The main purpose of this study is to explore the changes of circulating fetuin-B in young women with pre-diabetes and to analyze the relationship between fet...

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Autores principales: Xia, Xuyun, Xue, Shiyao, Yang, Gangyi, Li, Yu, Liu, Hua, Chen, Chen, Li, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381879/
https://www.ncbi.nlm.nih.gov/pubmed/34484983
http://dx.doi.org/10.7717/peerj.11869
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author Xia, Xuyun
Xue, Shiyao
Yang, Gangyi
Li, Yu
Liu, Hua
Chen, Chen
Li, Ling
author_facet Xia, Xuyun
Xue, Shiyao
Yang, Gangyi
Li, Yu
Liu, Hua
Chen, Chen
Li, Ling
author_sort Xia, Xuyun
collection PubMed
description BACKGROUND AND AIMS: Fetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes. The main purpose of this study is to explore the changes of circulating fetuin-B in young women with pre-diabetes and to analyze the relationship between fetuin-B and the occurrence and development of IR. METHODS: A total of 304 women were enrolled in this study and subjected to both OGTT and EHC. A subgroup of 26 overweight/obese womenwas treated with Lira for 24 weeks. serum fetuin-B concentrations were measured by ELISA. RESULTS: In IGT and IR-NG groups, serum fetuin-B levels were higher than those in the NGT group. The serum fetuin-B levels in the IGT group were higher than those in the IR-NG group. serum fetuin-B was positively correlated with BMI, WHR, 2h-BG, FIns, HbA1c, and HOMA2-IR, but negatively correlated with the M-value in all study populations. Multiple stepwise regression analysis showed that the M-value was independently and inversely associated with serum fetuin-B. Logistic regression analysis showed that serum fetuin-B was independently associated with IGT and significantly increased the risk of IGT. During the OGTT, serum fetuin-B increased significantly in the NGT group, but there were no significant changes in other groups. During the EHC, serum fetuin-B increased in the IGT group, but there was no change in other groups. After Lira intervention, serum fetuin-B decreased significantly in IGT women. CONCLUSIONS: serum fetuin-B levels are elevated in young women with IR or IGT and may be associated with IR.
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spelling pubmed-83818792021-09-02 Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide Xia, Xuyun Xue, Shiyao Yang, Gangyi Li, Yu Liu, Hua Chen, Chen Li, Ling PeerJ Clinical Trials BACKGROUND AND AIMS: Fetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes. The main purpose of this study is to explore the changes of circulating fetuin-B in young women with pre-diabetes and to analyze the relationship between fetuin-B and the occurrence and development of IR. METHODS: A total of 304 women were enrolled in this study and subjected to both OGTT and EHC. A subgroup of 26 overweight/obese womenwas treated with Lira for 24 weeks. serum fetuin-B concentrations were measured by ELISA. RESULTS: In IGT and IR-NG groups, serum fetuin-B levels were higher than those in the NGT group. The serum fetuin-B levels in the IGT group were higher than those in the IR-NG group. serum fetuin-B was positively correlated with BMI, WHR, 2h-BG, FIns, HbA1c, and HOMA2-IR, but negatively correlated with the M-value in all study populations. Multiple stepwise regression analysis showed that the M-value was independently and inversely associated with serum fetuin-B. Logistic regression analysis showed that serum fetuin-B was independently associated with IGT and significantly increased the risk of IGT. During the OGTT, serum fetuin-B increased significantly in the NGT group, but there were no significant changes in other groups. During the EHC, serum fetuin-B increased in the IGT group, but there was no change in other groups. After Lira intervention, serum fetuin-B decreased significantly in IGT women. CONCLUSIONS: serum fetuin-B levels are elevated in young women with IR or IGT and may be associated with IR. PeerJ Inc. 2021-08-20 /pmc/articles/PMC8381879/ /pubmed/34484983 http://dx.doi.org/10.7717/peerj.11869 Text en ©2021 Xia et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Clinical Trials
Xia, Xuyun
Xue, Shiyao
Yang, Gangyi
Li, Yu
Liu, Hua
Chen, Chen
Li, Ling
Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide
title Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide
title_full Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide
title_fullStr Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide
title_full_unstemmed Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide
title_short Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide
title_sort association of serum fetuin-b with insulin resistance and pre-diabetes in young chinese women: evidence from a cross-sectional study and effect of liraglutide
topic Clinical Trials
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381879/
https://www.ncbi.nlm.nih.gov/pubmed/34484983
http://dx.doi.org/10.7717/peerj.11869
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