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Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS

CONTEXT: Ambrisentan is an oral endothelin-receptor antagonist (ERA). However, there is no report on the interaction between ambrisentan and shikonin. OBJECTIVE: To investigate the effect of shikonin on ambrisentan metabolism in vivo and in vitro. MATERIALS AND METHODS: This study developed an ultra...

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Detalles Bibliográficos
Autores principales:	Lan, Tian, Fang, Ping, Ye, Xuemei, Lan, Xia, Xu, Ren-ai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381972/ https://www.ncbi.nlm.nih.gov/pubmed/34410882 http://dx.doi.org/10.1080/13880209.2021.1964544

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