Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a

Here we report de novo macrocyclic peptide binders to Wnt3a, a member of the Wnt protein family. By means of the Random non-standard Peptides Integrated Discovery (RaPID) system, we have performed in vitro selection against the complex of mouse Wnt3a (mWnt3a) with human afamin (hAFM) to discover mac...

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Detalles Bibliográficos
Autores principales: Otero-Ramirez, Manuel E., Matoba, Kyoko, Mihara, Emiko, Passioura, Toby, Takagi, Junichi, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382136/
https://www.ncbi.nlm.nih.gov/pubmed/34458746
http://dx.doi.org/10.1039/d0cb00016g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382136/
https://www.ncbi.nlm.nih.gov/pubmed/34458746
http://dx.doi.org/10.1039/d0cb00016g

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