Detection of COVID-19 from chest x-ray images using transfer learning

Purpose: The objective of this study is to develop and evaluate a fully automated, deep learning-based method for detection of COVID-19 infection from chest x-ray images. Approach: The proposed model was developed by replacing the final classifier layer in DenseNet201 with a new network consisting of global averaging layer, batch normalization layer, a dense layer with ReLU activation, and a final classification layer. Then, we performed an end-to-end training using the initial pretrained weights on all the layers. Our model was trained using a total of 8644 images with 4000 images each in normal and pneumonia cases and 644 in COVID-19 cases representing a large real dataset. The proposed method was evaluated based on accuracy, sensitivity, specificity, ROC curve, and [Formula: see text]-score using a test dataset comprising 1729 images (129 COVID-19, 800 normal, and 800 pneumonia). As a benchmark, we also compared the results of our method with those of seven state-of-the-art pretrained models and with a lightweight CNN architecture designed from scratch. Results: The proposed model based on DenseNet201 was able to achieve an accuracy of 94% in detecting COVID-19 and an overall accuracy of 92.19%. The model was able to achieve an AUC of 0.99 for COVID-19, 0.97 for normal, and 0.97 for pneumonia. The model was able to outperform alternative models in terms of overall accuracy, sensitivity, and specificity. Conclusions: Our proposed automated diagnostic model yielded an accuracy of 94% in the initial screening of COVID-19 patients and an overall accuracy of 92.19% using chest x-ray images.