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Intravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain

BACKGROUND: Activation of intravesical protease activated receptor 4 (PAR4) leads to release of urothelial macrophage migration inhibitory factor (MIF). MIF then binds to urothelial MIF receptors to release urothelial high mobility group box-1 (HMGB1) and elicit bladder hyperalgesia. Since MIF binds...

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Detalles Bibliográficos
Autores principales:	Ye, Shaojing, Ma, Fei, Mahmood, Dlovan F. D., Meyer-Siegler, Katherine L., Menard, Raymond E., Hunt, David E., Leng, Lin, Bucala, Richard, Vera, Pedro L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382170/ https://www.ncbi.nlm.nih.gov/pubmed/34424927 http://dx.doi.org/10.1371/journal.pone.0255975

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