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Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018

SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age...

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Autores principales: Shi, Qiqi, Wang, Ran, Zhang, Huifeng, Shan, Yaping, Ye, Ming, Jia, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382197/
https://www.ncbi.nlm.nih.gov/pubmed/34424900
http://dx.doi.org/10.1371/journal.pone.0254590
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author Shi, Qiqi
Wang, Ran
Zhang, Huifeng
Shan, Yaping
Ye, Ming
Jia, Bing
author_facet Shi, Qiqi
Wang, Ran
Zhang, Huifeng
Shan, Yaping
Ye, Ming
Jia, Bing
author_sort Shi, Qiqi
collection PubMed
description SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age examined in the 2001–2018 National health and Nutrition Examination Survey. We examined the association between SUA and CVD risk factors. The overall mean SUA level was 5.00±1.24mg/dl. Restricted cubic spline analysis results revealed SUA was inversely associated with HDL-C and SPISE and positively associated with TC, TG, LDL-C, nonHDL-C, insulin, SBP and DBP after full adjustment. Multiple logistic analyses showed SUA level was independently associated with high TC, high TG, high nonHDL-C and low HDL-C (all p<0.05). Furthermore, females in the highest quartile of SUA had significantly higher odds for elevated BP (OR = 2.38, 95%CI:1.02–5.54, P<0.05) and high TC (OR = 2.22, 95%CI: 1.49–3.30, P<0.001), which not observed in males. Increased levels of SUA were associated with increased odds of various cardiovascular risk factors in American adolescents, especially females.
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spelling pubmed-83821972021-08-24 Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018 Shi, Qiqi Wang, Ran Zhang, Huifeng Shan, Yaping Ye, Ming Jia, Bing PLoS One Research Article SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age examined in the 2001–2018 National health and Nutrition Examination Survey. We examined the association between SUA and CVD risk factors. The overall mean SUA level was 5.00±1.24mg/dl. Restricted cubic spline analysis results revealed SUA was inversely associated with HDL-C and SPISE and positively associated with TC, TG, LDL-C, nonHDL-C, insulin, SBP and DBP after full adjustment. Multiple logistic analyses showed SUA level was independently associated with high TC, high TG, high nonHDL-C and low HDL-C (all p<0.05). Furthermore, females in the highest quartile of SUA had significantly higher odds for elevated BP (OR = 2.38, 95%CI:1.02–5.54, P<0.05) and high TC (OR = 2.22, 95%CI: 1.49–3.30, P<0.001), which not observed in males. Increased levels of SUA were associated with increased odds of various cardiovascular risk factors in American adolescents, especially females. Public Library of Science 2021-08-23 /pmc/articles/PMC8382197/ /pubmed/34424900 http://dx.doi.org/10.1371/journal.pone.0254590 Text en © 2021 Shi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Shi, Qiqi
Wang, Ran
Zhang, Huifeng
Shan, Yaping
Ye, Ming
Jia, Bing
Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018
title Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018
title_full Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018
title_fullStr Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018
title_full_unstemmed Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018
title_short Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018
title_sort association between serum uric acid and cardiovascular disease risk factors in adolescents in america: 2001-2018
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382197/
https://www.ncbi.nlm.nih.gov/pubmed/34424900
http://dx.doi.org/10.1371/journal.pone.0254590
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