Cargando…
Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018
SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382197/ https://www.ncbi.nlm.nih.gov/pubmed/34424900 http://dx.doi.org/10.1371/journal.pone.0254590 |
_version_ | 1783741505154842624 |
---|---|
author | Shi, Qiqi Wang, Ran Zhang, Huifeng Shan, Yaping Ye, Ming Jia, Bing |
author_facet | Shi, Qiqi Wang, Ran Zhang, Huifeng Shan, Yaping Ye, Ming Jia, Bing |
author_sort | Shi, Qiqi |
collection | PubMed |
description | SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age examined in the 2001–2018 National health and Nutrition Examination Survey. We examined the association between SUA and CVD risk factors. The overall mean SUA level was 5.00±1.24mg/dl. Restricted cubic spline analysis results revealed SUA was inversely associated with HDL-C and SPISE and positively associated with TC, TG, LDL-C, nonHDL-C, insulin, SBP and DBP after full adjustment. Multiple logistic analyses showed SUA level was independently associated with high TC, high TG, high nonHDL-C and low HDL-C (all p<0.05). Furthermore, females in the highest quartile of SUA had significantly higher odds for elevated BP (OR = 2.38, 95%CI:1.02–5.54, P<0.05) and high TC (OR = 2.22, 95%CI: 1.49–3.30, P<0.001), which not observed in males. Increased levels of SUA were associated with increased odds of various cardiovascular risk factors in American adolescents, especially females. |
format | Online Article Text |
id | pubmed-8382197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83821972021-08-24 Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018 Shi, Qiqi Wang, Ran Zhang, Huifeng Shan, Yaping Ye, Ming Jia, Bing PLoS One Research Article SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age examined in the 2001–2018 National health and Nutrition Examination Survey. We examined the association between SUA and CVD risk factors. The overall mean SUA level was 5.00±1.24mg/dl. Restricted cubic spline analysis results revealed SUA was inversely associated with HDL-C and SPISE and positively associated with TC, TG, LDL-C, nonHDL-C, insulin, SBP and DBP after full adjustment. Multiple logistic analyses showed SUA level was independently associated with high TC, high TG, high nonHDL-C and low HDL-C (all p<0.05). Furthermore, females in the highest quartile of SUA had significantly higher odds for elevated BP (OR = 2.38, 95%CI:1.02–5.54, P<0.05) and high TC (OR = 2.22, 95%CI: 1.49–3.30, P<0.001), which not observed in males. Increased levels of SUA were associated with increased odds of various cardiovascular risk factors in American adolescents, especially females. Public Library of Science 2021-08-23 /pmc/articles/PMC8382197/ /pubmed/34424900 http://dx.doi.org/10.1371/journal.pone.0254590 Text en © 2021 Shi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Shi, Qiqi Wang, Ran Zhang, Huifeng Shan, Yaping Ye, Ming Jia, Bing Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018 |
title | Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018 |
title_full | Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018 |
title_fullStr | Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018 |
title_full_unstemmed | Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018 |
title_short | Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018 |
title_sort | association between serum uric acid and cardiovascular disease risk factors in adolescents in america: 2001-2018 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382197/ https://www.ncbi.nlm.nih.gov/pubmed/34424900 http://dx.doi.org/10.1371/journal.pone.0254590 |
work_keys_str_mv | AT shiqiqi associationbetweenserumuricacidandcardiovasculardiseaseriskfactorsinadolescentsinamerica20012018 AT wangran associationbetweenserumuricacidandcardiovasculardiseaseriskfactorsinadolescentsinamerica20012018 AT zhanghuifeng associationbetweenserumuricacidandcardiovasculardiseaseriskfactorsinadolescentsinamerica20012018 AT shanyaping associationbetweenserumuricacidandcardiovasculardiseaseriskfactorsinadolescentsinamerica20012018 AT yeming associationbetweenserumuricacidandcardiovasculardiseaseriskfactorsinadolescentsinamerica20012018 AT jiabing associationbetweenserumuricacidandcardiovasculardiseaseriskfactorsinadolescentsinamerica20012018 |