Frequency of Heterozygous Parkin (PRKN) Variants and Penetrance of Parkinson's Disease Risk Markers in the Population-Based CHRIS Cohort

Mutations in the Parkin (PRKN) gene are the most frequent cause of autosomal recessive early-onset Parkinson's disease (PD). Heterozygous PRKN mutation carriers might also be at increased risk for developing clinical symptoms of PD. Given the high frequency of heterozygous mutations in the gene...

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Detalles Bibliográficos
Autores principales: Castelo Rueda, Maria Paulina, Raftopoulou, Athina, Gögele, Martin, Borsche, Max, Emmert, David, Fuchsberger, Christian, Hantikainen, Essi M., Vukovic, Vladimir, Klein, Christine, Pramstaller, Peter P., Pichler, Irene, Hicks, Andrew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382284/
https://www.ncbi.nlm.nih.gov/pubmed/34434164
http://dx.doi.org/10.3389/fneur.2021.706145

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