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Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance

INTRODUCTION: Arthropod-borne viruses (arboviruses) cause morbidity and mortality in humans and domestic animals worldwide. The percentage of population immunity or susceptibility to these viruses in Ecuador is unknown. OBJECTIVES: To investigate the proportion of Ecuadorian populations with IgG ant...

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Autores principales: Gutiérrez-Vera, Ernesto, Patiño, Leandro, Castillo-Segovia, Martha, Valencia, Víctor Mora-, Montesdeoca-Agurto, Julio, Regato-Arrata, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Nacional de Salud 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382292/
https://www.ncbi.nlm.nih.gov/pubmed/34214266
http://dx.doi.org/10.7705/biomedica.5623
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author Gutiérrez-Vera, Ernesto
Patiño, Leandro
Castillo-Segovia, Martha
Valencia, Víctor Mora-
Montesdeoca-Agurto, Julio
Regato-Arrata, Mary
author_facet Gutiérrez-Vera, Ernesto
Patiño, Leandro
Castillo-Segovia, Martha
Valencia, Víctor Mora-
Montesdeoca-Agurto, Julio
Regato-Arrata, Mary
author_sort Gutiérrez-Vera, Ernesto
collection PubMed
description INTRODUCTION: Arthropod-borne viruses (arboviruses) cause morbidity and mortality in humans and domestic animals worldwide. The percentage of population immunity or susceptibility to these viruses in Ecuador is unknown. OBJECTIVES: To investigate the proportion of Ecuadorian populations with IgG antibodies (Abs) (past exposure/immunity) and IgM Abs (current exposure) against flaviviruses and alphaviruses and to study the activity of these viruses in Ecuador. MATERIALS AND METHODS: During 2009-2011, we conducted a serosurvey for selected arboviruses in humans (n=1,842), equines (n=149), and sentinel hamsters (n=84) at two coastal locations and one in the Amazon basin (Eastern Ecuador) using enzyme-linked immunosorbent assay and hemagglutination inhibition test. RESULTS: From 20.63% to 63.61% of humans showed IgG-antibodies for the flaviviruses: Dengue virus (DENV), yellow fever virus (YFV) Saint Louis encephalitis virus, and West Nile virus (WNV); from 4.67% to 8.63% showed IgG-Abs for the alphaviruses: Venezuelan equine encephalitis virus, eastern equine encephalitis virus, and western equine encephalitis virus. IgM-Abs were found for DENV and WNV. Equines and hamsters showed antibodies to alphaviruses in all locations; two hamsters seroconverted to YFV in the Amazonia. CONCLUSIONS: The results show a YFV vaccination history and suggest the activity of arboviruses not included in the current surveillance scheme. Enhanced arbovirus and mosquito surveillance, as well as continued YFV vaccination and evaluation of its coverage/ effectiveness, are recommended.
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spelling pubmed-83822922021-08-24 Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance Gutiérrez-Vera, Ernesto Patiño, Leandro Castillo-Segovia, Martha Valencia, Víctor Mora- Montesdeoca-Agurto, Julio Regato-Arrata, Mary Biomedica Original Article INTRODUCTION: Arthropod-borne viruses (arboviruses) cause morbidity and mortality in humans and domestic animals worldwide. The percentage of population immunity or susceptibility to these viruses in Ecuador is unknown. OBJECTIVES: To investigate the proportion of Ecuadorian populations with IgG antibodies (Abs) (past exposure/immunity) and IgM Abs (current exposure) against flaviviruses and alphaviruses and to study the activity of these viruses in Ecuador. MATERIALS AND METHODS: During 2009-2011, we conducted a serosurvey for selected arboviruses in humans (n=1,842), equines (n=149), and sentinel hamsters (n=84) at two coastal locations and one in the Amazon basin (Eastern Ecuador) using enzyme-linked immunosorbent assay and hemagglutination inhibition test. RESULTS: From 20.63% to 63.61% of humans showed IgG-antibodies for the flaviviruses: Dengue virus (DENV), yellow fever virus (YFV) Saint Louis encephalitis virus, and West Nile virus (WNV); from 4.67% to 8.63% showed IgG-Abs for the alphaviruses: Venezuelan equine encephalitis virus, eastern equine encephalitis virus, and western equine encephalitis virus. IgM-Abs were found for DENV and WNV. Equines and hamsters showed antibodies to alphaviruses in all locations; two hamsters seroconverted to YFV in the Amazonia. CONCLUSIONS: The results show a YFV vaccination history and suggest the activity of arboviruses not included in the current surveillance scheme. Enhanced arbovirus and mosquito surveillance, as well as continued YFV vaccination and evaluation of its coverage/ effectiveness, are recommended. Instituto Nacional de Salud 2021-06-15 /pmc/articles/PMC8382292/ /pubmed/34214266 http://dx.doi.org/10.7705/biomedica.5623 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
Gutiérrez-Vera, Ernesto
Patiño, Leandro
Castillo-Segovia, Martha
Valencia, Víctor Mora-
Montesdeoca-Agurto, Julio
Regato-Arrata, Mary
Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance
title Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance
title_full Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance
title_fullStr Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance
title_full_unstemmed Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance
title_short Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance
title_sort seroprevalence of arboviruses in ecuador: implications for improved surveillance
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382292/
https://www.ncbi.nlm.nih.gov/pubmed/34214266
http://dx.doi.org/10.7705/biomedica.5623
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