Severe deficiency of the voltage-gated sodium channel Na(V)1.2 elevates neuronal excitability in adult mice

Scn2a encodes the voltage-gated sodium channel Na(V)1.2, a main mediator of neuronal action potential firing. The current paradigm suggests that Na(V)1.2 gain-of-function variants enhance neuronal excitability, resulting in epilepsy, whereas Na(V)1.2 deficiency impairs neuronal excitability, contrib...

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Detalles Bibliográficos
Autores principales: Zhang, Jingliang, Chen, Xiaoling, Eaton, Muriel, Wu, Jiaxiang, Ma, Zhixiong, Lai, Shirong, Park, Anthony, Ahmad, Talha S., Que, Zhefu, Lee, Ji Hea, Xiao, Tiange, Li, Yuansong, Wang, Yujia, Olivero-Acosta, Maria I., Schaber, James A., Jayant, Krishna, Yuan, Chongli, Huang, Zhuo, Lanman, Nadia A., Skarnes, William C., Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382316/
https://www.ncbi.nlm.nih.gov/pubmed/34348148
http://dx.doi.org/10.1016/j.celrep.2021.109495

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