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Successful Use of Kidneys from a Deceased Donor with Active Herpes Zoster Infection

BACKGROUND: The limited donor pool and increasing recipient wait list require a reevaluation of kidney organ suitability for transplantation. Use of higher infectious risk organs that were previously discarded may help improve access to transplantation and reduce patient mortality without placing pa...

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Autores principales: Vinson, Amanda J., Chauhan, Prakash, Daley, Christopher, De Silva, Himanthi, Tennankore, Karthik K., Bonnar, Paul, West, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382547/
https://www.ncbi.nlm.nih.gov/pubmed/34434591
http://dx.doi.org/10.1155/2021/7719041
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author Vinson, Amanda J.
Chauhan, Prakash
Daley, Christopher
De Silva, Himanthi
Tennankore, Karthik K.
Bonnar, Paul
West, Kenneth A.
author_facet Vinson, Amanda J.
Chauhan, Prakash
Daley, Christopher
De Silva, Himanthi
Tennankore, Karthik K.
Bonnar, Paul
West, Kenneth A.
author_sort Vinson, Amanda J.
collection PubMed
description BACKGROUND: The limited donor pool and increasing recipient wait list require a reevaluation of kidney organ suitability for transplantation. Use of higher infectious risk organs that were previously discarded may help improve access to transplantation and reduce patient mortality without placing patients at a higher risk of poor posttransplant outcomes. There is very little data available regarding the safe use of kidney organs from deceased donors with varicella zoster virus infection at the time of organ retrieval. Case Presentation. Here, we report a case of successful transplantation of both kidneys from a deceased donor with active herpes zoster infection at the time of organ retrieval. Recipients were treated preemptively with acyclovir. At 4 months posttransplant, both kidney recipients experienced no infectious complications and were off dialysis with functioning transplant grafts. CONCLUSIONS: The use of kidney organs from donors with active herpes zoster infection appears to be a safe option to expand the kidney donor pool.
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spelling pubmed-83825472021-08-24 Successful Use of Kidneys from a Deceased Donor with Active Herpes Zoster Infection Vinson, Amanda J. Chauhan, Prakash Daley, Christopher De Silva, Himanthi Tennankore, Karthik K. Bonnar, Paul West, Kenneth A. Case Rep Transplant Case Report BACKGROUND: The limited donor pool and increasing recipient wait list require a reevaluation of kidney organ suitability for transplantation. Use of higher infectious risk organs that were previously discarded may help improve access to transplantation and reduce patient mortality without placing patients at a higher risk of poor posttransplant outcomes. There is very little data available regarding the safe use of kidney organs from deceased donors with varicella zoster virus infection at the time of organ retrieval. Case Presentation. Here, we report a case of successful transplantation of both kidneys from a deceased donor with active herpes zoster infection at the time of organ retrieval. Recipients were treated preemptively with acyclovir. At 4 months posttransplant, both kidney recipients experienced no infectious complications and were off dialysis with functioning transplant grafts. CONCLUSIONS: The use of kidney organs from donors with active herpes zoster infection appears to be a safe option to expand the kidney donor pool. Hindawi 2021-08-16 /pmc/articles/PMC8382547/ /pubmed/34434591 http://dx.doi.org/10.1155/2021/7719041 Text en Copyright © 2021 Amanda J. Vinson et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Vinson, Amanda J.
Chauhan, Prakash
Daley, Christopher
De Silva, Himanthi
Tennankore, Karthik K.
Bonnar, Paul
West, Kenneth A.
Successful Use of Kidneys from a Deceased Donor with Active Herpes Zoster Infection
title Successful Use of Kidneys from a Deceased Donor with Active Herpes Zoster Infection
title_full Successful Use of Kidneys from a Deceased Donor with Active Herpes Zoster Infection
title_fullStr Successful Use of Kidneys from a Deceased Donor with Active Herpes Zoster Infection
title_full_unstemmed Successful Use of Kidneys from a Deceased Donor with Active Herpes Zoster Infection
title_short Successful Use of Kidneys from a Deceased Donor with Active Herpes Zoster Infection
title_sort successful use of kidneys from a deceased donor with active herpes zoster infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382547/
https://www.ncbi.nlm.nih.gov/pubmed/34434591
http://dx.doi.org/10.1155/2021/7719041
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