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An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020)
This review provides a brief survey of chiral separation of pharmaceutically active substances published over the last 3 years (2018–2020). Chiral separation of drugs is an important area of research. The control of enantiomeric purity and determination of individual enantiomeric drug molecules is a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382579/ https://www.ncbi.nlm.nih.gov/pubmed/34456367 http://dx.doi.org/10.1007/s00706-021-02832-5 |
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author | Grybinik, Sofiya Bosakova, Zuzana |
author_facet | Grybinik, Sofiya Bosakova, Zuzana |
author_sort | Grybinik, Sofiya |
collection | PubMed |
description | This review provides a brief survey of chiral separation of pharmaceutically active substances published over the last 3 years (2018–2020). Chiral separation of drugs is an important area of research. The control of enantiomeric purity and determination of individual enantiomeric drug molecules is a necessity especially for clinical, analytical, and regulatory purposes. Among chromatographic resolution methods, high-performance liquid chromatography based on chiral stationary phases remains the most popular and effective method used for chiral separation of various drugs. In this review, attention is paid to several classes of chiral stationary phases that have been the most frequently used for drug enantioseparation during this period. GRAPHIC ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-8382579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-83825792021-08-24 An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020) Grybinik, Sofiya Bosakova, Zuzana Monatsh Chem Review This review provides a brief survey of chiral separation of pharmaceutically active substances published over the last 3 years (2018–2020). Chiral separation of drugs is an important area of research. The control of enantiomeric purity and determination of individual enantiomeric drug molecules is a necessity especially for clinical, analytical, and regulatory purposes. Among chromatographic resolution methods, high-performance liquid chromatography based on chiral stationary phases remains the most popular and effective method used for chiral separation of various drugs. In this review, attention is paid to several classes of chiral stationary phases that have been the most frequently used for drug enantioseparation during this period. GRAPHIC ABSTRACT: [Image: see text] Springer Vienna 2021-08-24 2021 /pmc/articles/PMC8382579/ /pubmed/34456367 http://dx.doi.org/10.1007/s00706-021-02832-5 Text en © Springer-Verlag GmbH Austria, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Grybinik, Sofiya Bosakova, Zuzana An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020) |
title | An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020) |
title_full | An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020) |
title_fullStr | An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020) |
title_full_unstemmed | An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020) |
title_short | An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020) |
title_sort | overview of chiral separations of pharmaceutically active substances by hplc (2018–2020) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382579/ https://www.ncbi.nlm.nih.gov/pubmed/34456367 http://dx.doi.org/10.1007/s00706-021-02832-5 |
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