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Endovascular Stent-Graft Repair of the Ascending Aorta: Assessment of a Specific Novel Stent-Graft Design in Phantom, Cadaveric, and Clinical Application
PURPOSE: To test a stent-graft specifically designed for the ascending aorta in phantom, cadaver, and clinical application, and to measure deployment accuracy to overcome limitations of existing devices. METHODS: A stent-graft has been designed with support wires to fixate the apices toward the inne...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382630/ https://www.ncbi.nlm.nih.gov/pubmed/34180002 http://dx.doi.org/10.1007/s00270-021-02859-5 |
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author | Hauck, Sven R. Kupferthaler, Alexander Stelzmüller, Marlies Eilenberg, Wolf Ehrlich, Marek Neumayer, Christoph Wolf, Florian Loewe, Christian Funovics, Martin A. |
author_facet | Hauck, Sven R. Kupferthaler, Alexander Stelzmüller, Marlies Eilenberg, Wolf Ehrlich, Marek Neumayer, Christoph Wolf, Florian Loewe, Christian Funovics, Martin A. |
author_sort | Hauck, Sven R. |
collection | PubMed |
description | PURPOSE: To test a stent-graft specifically designed for the ascending aorta in phantom, cadaver, and clinical application, and to measure deployment accuracy to overcome limitations of existing devices. METHODS: A stent-graft has been designed with support wires to fixate the apices toward the inner curvature, thereby eliminating the forward movement of the proximal end which can happen with circumferential tip capture systems. The device was deployed in three aortic phantoms, and in four cadavers, deployment precision was measured. Subsequently, the device was implanted in a patient to exclude a pseudoaneurysm originating from the distal anastomosis after ascending aortic replacement. RESULTS: The stent-grafts were successfully deployed in all phantoms and cadavers. Deployment accuracy of the proximal end of the stent-graft was within 1 mm proximally and 14 mm distally to the intended landing zone on the inner curvature, and 2–8 mm distal to the intended landing zone on the outer curvature. In clinical application, the pseudoaneurysm could be successfully excluded without complications. CONCLUSION: The novel stent-graft design promises accurate placement in the ascending aorta. The differential deployment of the apices at the inner and outer curvatures allows deployment perpendicular to the aortic axis. LEVEL OF EVIDENCE: No level of evidence. |
format | Online Article Text |
id | pubmed-8382630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-83826302021-09-09 Endovascular Stent-Graft Repair of the Ascending Aorta: Assessment of a Specific Novel Stent-Graft Design in Phantom, Cadaveric, and Clinical Application Hauck, Sven R. Kupferthaler, Alexander Stelzmüller, Marlies Eilenberg, Wolf Ehrlich, Marek Neumayer, Christoph Wolf, Florian Loewe, Christian Funovics, Martin A. Cardiovasc Intervent Radiol Laboratory Investigation PURPOSE: To test a stent-graft specifically designed for the ascending aorta in phantom, cadaver, and clinical application, and to measure deployment accuracy to overcome limitations of existing devices. METHODS: A stent-graft has been designed with support wires to fixate the apices toward the inner curvature, thereby eliminating the forward movement of the proximal end which can happen with circumferential tip capture systems. The device was deployed in three aortic phantoms, and in four cadavers, deployment precision was measured. Subsequently, the device was implanted in a patient to exclude a pseudoaneurysm originating from the distal anastomosis after ascending aortic replacement. RESULTS: The stent-grafts were successfully deployed in all phantoms and cadavers. Deployment accuracy of the proximal end of the stent-graft was within 1 mm proximally and 14 mm distally to the intended landing zone on the inner curvature, and 2–8 mm distal to the intended landing zone on the outer curvature. In clinical application, the pseudoaneurysm could be successfully excluded without complications. CONCLUSION: The novel stent-graft design promises accurate placement in the ascending aorta. The differential deployment of the apices at the inner and outer curvatures allows deployment perpendicular to the aortic axis. LEVEL OF EVIDENCE: No level of evidence. Springer US 2021-06-27 2021 /pmc/articles/PMC8382630/ /pubmed/34180002 http://dx.doi.org/10.1007/s00270-021-02859-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Laboratory Investigation Hauck, Sven R. Kupferthaler, Alexander Stelzmüller, Marlies Eilenberg, Wolf Ehrlich, Marek Neumayer, Christoph Wolf, Florian Loewe, Christian Funovics, Martin A. Endovascular Stent-Graft Repair of the Ascending Aorta: Assessment of a Specific Novel Stent-Graft Design in Phantom, Cadaveric, and Clinical Application |
title | Endovascular Stent-Graft Repair of the Ascending Aorta: Assessment of a Specific Novel Stent-Graft Design in Phantom, Cadaveric, and Clinical Application |
title_full | Endovascular Stent-Graft Repair of the Ascending Aorta: Assessment of a Specific Novel Stent-Graft Design in Phantom, Cadaveric, and Clinical Application |
title_fullStr | Endovascular Stent-Graft Repair of the Ascending Aorta: Assessment of a Specific Novel Stent-Graft Design in Phantom, Cadaveric, and Clinical Application |
title_full_unstemmed | Endovascular Stent-Graft Repair of the Ascending Aorta: Assessment of a Specific Novel Stent-Graft Design in Phantom, Cadaveric, and Clinical Application |
title_short | Endovascular Stent-Graft Repair of the Ascending Aorta: Assessment of a Specific Novel Stent-Graft Design in Phantom, Cadaveric, and Clinical Application |
title_sort | endovascular stent-graft repair of the ascending aorta: assessment of a specific novel stent-graft design in phantom, cadaveric, and clinical application |
topic | Laboratory Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382630/ https://www.ncbi.nlm.nih.gov/pubmed/34180002 http://dx.doi.org/10.1007/s00270-021-02859-5 |
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