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NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements
ABSTRACT: Accurate and reproducible measurement of blood flow profile is very important in many clinical investigations for diagnosing cardiovascular disorders. Given that many factors could affect human circulation, and several parameters must be set to properly evaluate blood flows with phase-cont...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382656/ https://www.ncbi.nlm.nih.gov/pubmed/34365590 http://dx.doi.org/10.1007/s11517-021-02390-2 |
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author | Gadda, Giacomo Cocozza, Sirio Gambaccini, Mauro Taibi, Angelo Tedeschi, Enrico Zamboni, Paolo Palma, Giuseppe |
author_facet | Gadda, Giacomo Cocozza, Sirio Gambaccini, Mauro Taibi, Angelo Tedeschi, Enrico Zamboni, Paolo Palma, Giuseppe |
author_sort | Gadda, Giacomo |
collection | PubMed |
description | ABSTRACT: Accurate and reproducible measurement of blood flow profile is very important in many clinical investigations for diagnosing cardiovascular disorders. Given that many factors could affect human circulation, and several parameters must be set to properly evaluate blood flows with phase-contrast techniques, we developed an MRI-compatible hydrodynamic phantom to simulate different physiological blood flows. The phantom included a programmable hydraulic pump connected to a series of pipes immersed in a solution mimicking human soft tissues, with a blood-mimicking fluid flowing in the pipes. The pump is able to shape and control the flow by driving a piston through a dedicated software. Periodic waveforms are used as input to the pump to move the fluid into the pipes, with synchronization of the MRI sequences to the flow waveforms. A dedicated software is used to extract and analyze flow data from magnitude and phase images. The match between the nominal and the measured flows was assessed, and the scope of phantom variables useful for a reliable calibration of an MRI system was accordingly defined. Results showed that the NO-HYPE phantom is a valuable tool for the assessment of MRI scanners and sequence design for the MR evaluation of blood flows. GRAPHICAL ABSTRACT: [Figure: see text] |
format | Online Article Text |
id | pubmed-8382656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-83826562021-09-09 NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements Gadda, Giacomo Cocozza, Sirio Gambaccini, Mauro Taibi, Angelo Tedeschi, Enrico Zamboni, Paolo Palma, Giuseppe Med Biol Eng Comput Original Article ABSTRACT: Accurate and reproducible measurement of blood flow profile is very important in many clinical investigations for diagnosing cardiovascular disorders. Given that many factors could affect human circulation, and several parameters must be set to properly evaluate blood flows with phase-contrast techniques, we developed an MRI-compatible hydrodynamic phantom to simulate different physiological blood flows. The phantom included a programmable hydraulic pump connected to a series of pipes immersed in a solution mimicking human soft tissues, with a blood-mimicking fluid flowing in the pipes. The pump is able to shape and control the flow by driving a piston through a dedicated software. Periodic waveforms are used as input to the pump to move the fluid into the pipes, with synchronization of the MRI sequences to the flow waveforms. A dedicated software is used to extract and analyze flow data from magnitude and phase images. The match between the nominal and the measured flows was assessed, and the scope of phantom variables useful for a reliable calibration of an MRI system was accordingly defined. Results showed that the NO-HYPE phantom is a valuable tool for the assessment of MRI scanners and sequence design for the MR evaluation of blood flows. GRAPHICAL ABSTRACT: [Figure: see text] Springer Berlin Heidelberg 2021-08-08 2021 /pmc/articles/PMC8382656/ /pubmed/34365590 http://dx.doi.org/10.1007/s11517-021-02390-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Gadda, Giacomo Cocozza, Sirio Gambaccini, Mauro Taibi, Angelo Tedeschi, Enrico Zamboni, Paolo Palma, Giuseppe NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements |
title | NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements |
title_full | NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements |
title_fullStr | NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements |
title_full_unstemmed | NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements |
title_short | NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements |
title_sort | no-hype: a novel hydrodynamic phantom for the evaluation of mri flow measurements |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382656/ https://www.ncbi.nlm.nih.gov/pubmed/34365590 http://dx.doi.org/10.1007/s11517-021-02390-2 |
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