Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes

Tolerogenic vaccinations using beta-cell antigens are attractive for type 1 diabetes prevention, but clinical trials have been disappointing. This is probably due to the late timing of intervention, when multiple auto-antibodies are already present. We therefore devised a strategy to introduce the i...

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Detalles Bibliográficos
Autores principales: Corcos, Noémie, Culina, Slobodan, Deligne, Claire, Lavaud, Cassandra, You, Sylvaine, Mallone, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382691/
https://www.ncbi.nlm.nih.gov/pubmed/34447366
http://dx.doi.org/10.3389/fimmu.2021.616215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382691/
https://www.ncbi.nlm.nih.gov/pubmed/34447366
http://dx.doi.org/10.3389/fimmu.2021.616215

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