Cargando…
Biological correlates before esophageal cancer screening and after diagnosis
Almost 50% of the world’s esophageal cancer (EC) cases occur in China, and the impact of cancer screening has long been a controversial topic. The study was designed to evaluate the biological correlates of EC screening and subsequent diagnosis in China. Based on the national cohort of esophageal ca...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382699/ https://www.ncbi.nlm.nih.gov/pubmed/34426626 http://dx.doi.org/10.1038/s41598-021-96548-5 |
_version_ | 1783741589548433408 |
---|---|
author | Zhu, Juan Ma, Shanrui Chen, Ru Xie, Shuanghua Liu, Zhengkui Li, Xinqing Wei, Wenqiang |
author_facet | Zhu, Juan Ma, Shanrui Chen, Ru Xie, Shuanghua Liu, Zhengkui Li, Xinqing Wei, Wenqiang |
author_sort | Zhu, Juan |
collection | PubMed |
description | Almost 50% of the world’s esophageal cancer (EC) cases occur in China, and the impact of cancer screening has long been a controversial topic. The study was designed to evaluate the biological correlates of EC screening and subsequent diagnosis in China. Based on the national cohort of esophageal cancer program, a prospective multicenter study in high-risk regions was conducted from 2017 to 2019. 61 participants received twice esophageal endoscopy screening and pathological biopsy successively (with a mean follow-up of 14.03 months). Box–Cox-power transformation and two-way repeated measures ANOVA were used to evaluate hormone cortisol and immunoglobulin (IgA, IgG, IgM) levels in plasma, reflecting their stress, immune function, and biological correlates before screening and after knowing the diagnosis. The median of cortisol, IgA, IgG, and IgM in pre-screening was 15.46 ug/dL, 1.86 g/L, 12.14 g/L, and 0.91 g/L, corresponding value at post-diagnosis was 15.30 ug/dL, 2.00 g/L, 12.79 g/L, and 0.94 g/L, respectively. No significant differences in biological indicators were found between normal and esophagitis and low-grade intraepithelial neoplasia before screening and after diagnosis. After normality transformation, cortisol, IgA, IgG and IgM levels were (0.25 ± 0.04) U/mL, (0.72 ± 0.13) (g/L), (2.44 ± 0.22) (g/L) and (0.98 ± 0.25) (g/L) before screening, (0.25 ± 0.05) U/mL, (0.70 ± 0.13) (g/L), (2.48 ± 0.21) (g/L) and (1.00 ± 0.25) (g/L) after diagnosis, respectively. Repeated Measures ANOVA showed that the main effects were significant on IgA levels between pre-screening and post-diagnosis (P = 0.019). No interaction effects on biological levels between pre-post screening and esophageal pathology, anxiety states (all P > 0.05). Little biological correlates were found both before screening and after diagnosis. Cortisol and IgA dropped less significantly, while IgM and IgA were increased slightly after diagnosis. Further multi-round longitudinal studies are needed to validate these results. |
format | Online Article Text |
id | pubmed-8382699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83826992021-09-01 Biological correlates before esophageal cancer screening and after diagnosis Zhu, Juan Ma, Shanrui Chen, Ru Xie, Shuanghua Liu, Zhengkui Li, Xinqing Wei, Wenqiang Sci Rep Article Almost 50% of the world’s esophageal cancer (EC) cases occur in China, and the impact of cancer screening has long been a controversial topic. The study was designed to evaluate the biological correlates of EC screening and subsequent diagnosis in China. Based on the national cohort of esophageal cancer program, a prospective multicenter study in high-risk regions was conducted from 2017 to 2019. 61 participants received twice esophageal endoscopy screening and pathological biopsy successively (with a mean follow-up of 14.03 months). Box–Cox-power transformation and two-way repeated measures ANOVA were used to evaluate hormone cortisol and immunoglobulin (IgA, IgG, IgM) levels in plasma, reflecting their stress, immune function, and biological correlates before screening and after knowing the diagnosis. The median of cortisol, IgA, IgG, and IgM in pre-screening was 15.46 ug/dL, 1.86 g/L, 12.14 g/L, and 0.91 g/L, corresponding value at post-diagnosis was 15.30 ug/dL, 2.00 g/L, 12.79 g/L, and 0.94 g/L, respectively. No significant differences in biological indicators were found between normal and esophagitis and low-grade intraepithelial neoplasia before screening and after diagnosis. After normality transformation, cortisol, IgA, IgG and IgM levels were (0.25 ± 0.04) U/mL, (0.72 ± 0.13) (g/L), (2.44 ± 0.22) (g/L) and (0.98 ± 0.25) (g/L) before screening, (0.25 ± 0.05) U/mL, (0.70 ± 0.13) (g/L), (2.48 ± 0.21) (g/L) and (1.00 ± 0.25) (g/L) after diagnosis, respectively. Repeated Measures ANOVA showed that the main effects were significant on IgA levels between pre-screening and post-diagnosis (P = 0.019). No interaction effects on biological levels between pre-post screening and esophageal pathology, anxiety states (all P > 0.05). Little biological correlates were found both before screening and after diagnosis. Cortisol and IgA dropped less significantly, while IgM and IgA were increased slightly after diagnosis. Further multi-round longitudinal studies are needed to validate these results. Nature Publishing Group UK 2021-08-23 /pmc/articles/PMC8382699/ /pubmed/34426626 http://dx.doi.org/10.1038/s41598-021-96548-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhu, Juan Ma, Shanrui Chen, Ru Xie, Shuanghua Liu, Zhengkui Li, Xinqing Wei, Wenqiang Biological correlates before esophageal cancer screening and after diagnosis |
title | Biological correlates before esophageal cancer screening and after diagnosis |
title_full | Biological correlates before esophageal cancer screening and after diagnosis |
title_fullStr | Biological correlates before esophageal cancer screening and after diagnosis |
title_full_unstemmed | Biological correlates before esophageal cancer screening and after diagnosis |
title_short | Biological correlates before esophageal cancer screening and after diagnosis |
title_sort | biological correlates before esophageal cancer screening and after diagnosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382699/ https://www.ncbi.nlm.nih.gov/pubmed/34426626 http://dx.doi.org/10.1038/s41598-021-96548-5 |
work_keys_str_mv | AT zhujuan biologicalcorrelatesbeforeesophagealcancerscreeningandafterdiagnosis AT mashanrui biologicalcorrelatesbeforeesophagealcancerscreeningandafterdiagnosis AT chenru biologicalcorrelatesbeforeesophagealcancerscreeningandafterdiagnosis AT xieshuanghua biologicalcorrelatesbeforeesophagealcancerscreeningandafterdiagnosis AT liuzhengkui biologicalcorrelatesbeforeesophagealcancerscreeningandafterdiagnosis AT lixinqing biologicalcorrelatesbeforeesophagealcancerscreeningandafterdiagnosis AT weiwenqiang biologicalcorrelatesbeforeesophagealcancerscreeningandafterdiagnosis |