Cargando…

Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation

Alzheimer’s disease is the leading cause of dementia and a defining hallmark is the progressive brain deposition of tau aggregates. The insidious accumulation of brain tau inclusions is also involved in a group of neurodegenerative diseases termed frontotemporal dementias. In all of these disorders,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Yuxing, Bell, Brach M., Giasson, Benoit I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382713/ https://www.ncbi.nlm.nih.gov/pubmed/34426645 http://dx.doi.org/10.1038/s41598-021-96627-7

Ejemplares similares

Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation
por: Xia, Yuxing, et al.
Publicado: (2023)

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
por: Cook, Casey, et al.
Publicado: (2014)

Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation
por: Xia, Yuxing, et al.
Publicado: (2023)

Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology
por: Paterno, Giavanna, et al.
Publicado: (2022)

Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies
por: Xia, Yuxing, et al.
Publicado: (2020)

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects
por: Lathuilière, Aurélien, et al.
Publicado: (2017)

“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies
por: Xia, Yuxing, et al.
Publicado: (2021)

Updated Measurement of the \tau Polarisation in \tau -> \tau(K)\nu_\tau
por: Moraes, D, et al.
Publicado: (1998)

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau
por: Croft, Cara L., et al.
Publicado: (2018)

Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice
por: Xia, Yuxing, et al.
Publicado: (2022)

Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites
por: Paterno, Giavanna, et al.
Publicado: (2023)

Measurement of the inclusive \tau -> K^0_s and the exclusive \tau -> K^*±\nu_\tau decays with DELPHI
por: Cavallo, F R, et al.
Publicado: (1994)

Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation
por: Li, Longfei, et al.
Publicado: (2022)

Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu(2+)
por: Ahmadi, Soha, et al.
Publicado: (2019)

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology
por: Pace, Michael C., et al.
Publicado: (2018)

Tau decays into $K*$ mesons
por: Albrecht, H, et al.
Publicado: (1995)

First observation of the decay $\tau^{-}$ --> K$^{-}\eta\nu_{ \tau}$
por: Bartelt, J
Publicado: (1996)

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment
por: Pir, Ghulam Jeelani, et al.
Publicado: (2018)

Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation
por: Acosta, Diana M., et al.
Publicado: (2021)

Measurement of tau - pi nu tau and tau - K nu tau Branching Ratios Using the OPAL Detector at LEP
por: CERN. Geneva
Publicado: (1993)

The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
por: Torii, Tomohiro, et al.
Publicado: (2022)

A measurement of tau --> K* nu_tau branching ratio using K^o calorimetric tagging
por: Cerutti, F, et al.
Publicado: (1993)

Analysis of tau - e nu nubar and tau - pi(K)nu
por: CERN. Geneva
Publicado: (1991)

Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension
por: Hu, Jiaxin, et al.
Publicado: (2023)

$\tau$ decay of $K^{+}$ in nuclear emulsion
por: CERN. Geneva. Track Chambers Division (TC)
Publicado: (2022)

$K^{0}_{S}$ production in $\tau$ decays
por: Barate, R, et al.
Publicado: (1997)

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau
por: Narasimhan, Sneha, et al.
Publicado: (2019)

Tau local structure shields an amyloid-forming motif and controls aggregation propensity
por: Chen, Dailu, et al.
Publicado: (2019)

Propagation of Tau aggregates
por: Goedert, Michel, et al.
Publicado: (2017)

EGCG impedes human Tau aggregation and interacts with Tau
por: Sonawane, Shweta Kishor, et al.
Publicado: (2020)

Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU
por: Bachmann, Sarah, et al.
Publicado: (2021)

Probing lepton flavour universality with $B^0 \to K^{*0} \tau^+ \tau^-$
por: Venkateswaran, Aravindhan
Publicado: (2022)

Tau decays into K^± and K^0_s with the DELPHI detector at LEP
por: Navarria, F L
Publicado: (1994)

The Effect of a ΔK280 Mutation on the Unfolded State of a Microtubule-Binding Repeat in Tau
por: Huang, Austin, et al.
Publicado: (2008)

Measurement of Branching Ratios and tau Polarization from tau to e nu nubar, tau to mu nu nubar, and tau to pi(K)nu
por: CERN. Geneva
Publicado: (1992)

Microtubule-binding core of the tau protein
por: El Mammeri, Nadia, et al.
Publicado: (2022)

Tau binding protein CAPON induces tau aggregation and neurodegeneration
por: Hashimoto, Shoko, et al.
Publicado: (2019)

Toxic tau: structural origins of tau aggregation in Alzheimer's disease
por: Mamun, Abdullah Al, et al.
Publicado: (2020)

Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics
por: Woo, Jung-A. A., et al.
Publicado: (2019)

Search for the rare $B^0 \to K^{*0} \tau^+ \tau^-$ decay at the LHCb experiment
por: Cerasoli, Jacopo
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fuqesf33i5t3c21p4k8is3rv3b