Cargando…

Functional characterization of miR-708 microRNA in telomerase positive and negative human cancer cells

Activation of a telomere length maintenance mechanism (TMM), including telomerase and alternative lengthening of telomeres (ALT), is essential for replicative immortality of tumor cells, although its regulatory mechanisms are incompletely understood. We conducted a microRNA (miRNA) microarray analys...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaul, Zeenia, Cheung, Caroline T. Y., Bhargava, Priyanshu, Sari, Anissa Notifa, Yu, Yue, Huifu, He, Bid, Hemant, Henson, Jeremy D., Groden, Joanna, Reddel, Roger R., Kaul, Sunil C., Wadhwa, Renu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382839/ https://www.ncbi.nlm.nih.gov/pubmed/34426596 http://dx.doi.org/10.1038/s41598-021-96096-y

Ejemplares similares

Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences
por: Yu, Yue, et al.
Publicado: (2017)

Loss-of-function screening to identify miRNAs involved in senescence: tumor suppressor activity of miRNA-335 and its new target CARF
por: Yu, Yue, et al.
Publicado: (2016)

Experimental Evidence for Therapeutic Potentials of Propolis
por: Bhargava, Priyanshu, et al.
Publicado: (2021)

Integration of conventional cell viability assays for reliable and reproducible read-outs: experimental evidence
por: Garg, Sukant, et al.
Publicado: (2018)

Combination of Withaferin-A and CAPE Provides Superior Anticancer Potency: Bioinformatics and Experimental Evidence to Their Molecular Targets and Mechanism of Action
por: Sari, Anissa Nofita, et al.
Publicado: (2020)

Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells
por: Wang, Jia, et al.
Publicado: (2020)

Relevance of mortalin to cancer cell stemness and cancer therapy
por: Yun, Chae-Ok, et al.
Publicado: (2017)

Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With γ-Cyclodextrin
por: Ishida, Yoshiyuki, et al.
Publicado: (2018)

Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers
por: Putri, Jayarani F., et al.
Publicado: (2019)

MicroRNA-296 is enriched in cancer cells and downregulates p21(WAF1) mRNA expression via interaction with its 3′ untranslated region
por: Yoon, A-rum, et al.
Publicado: (2011)

Tumor suppressor activity of miR-451: Identification of CARF as a new target
por: Li, Ling, et al.
Publicado: (2018)

Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells
por: Nigam, Nupur, et al.
Publicado: (2015)

CARF enrichment promotes epithelial–mesenchymal transition via Wnt/β-catenin signaling: its clinical relevance and potential as a therapeutic target
por: Kalra, Rajkumar S., et al.
Publicado: (2018)

Identification and Characterization of Mortaparib(Plus)—A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms
por: Sari, Anissa Nofita, et al.
Publicado: (2021)

Molecular Characterization and Enhancement of Anticancer Activity of Caffeic Acid Phenethyl Ester by γ Cyclodextrin
por: Wadhwa, Renu, et al.
Publicado: (2016)

Five dysfunctional telomeres predict onset of senescence in human cells
por: Kaul, Zeenia, et al.
Publicado: (2012)

Mutant p53(L194F) Harboring Luminal-A Breast Cancer Cells Are Refractory to Apoptosis and Cell Cycle Arrest in Response to Mortaparib(Plus), a Multimodal Small Molecule Inhibitor
por: Elwakeel, Ahmed, et al.
Publicado: (2021)

Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells
por: Acharya, Samir, et al.
Publicado: (2014)

Caffeic acid phenethyl ester (CAPE) confers wild type p53 function in p53(Y220C) mutant: bioinformatics and experimental evidence
por: Radhakrishnan, Navaneethan, et al.
Publicado: (2021)

Comparative computational and experimental analyses of some natural small molecules to restore transcriptional activation function of p53 in cancer cells harbouring wild type and p53(Ser46) mutant
por: Shefrin, Seyad, et al.
Publicado: (2022)

Identification of a new member of Mortaparib class of inhibitors that target mortalin and PARP1
por: Meidinna, Hazna Noor, et al.
Publicado: (2022)

Molecular Insights into the Antistress Potentials of Brazilian Green Propolis Extract and Its Constituent Artepillin C
por: Kaul, Ashish, et al.
Publicado: (2021)

Water Extract from the Leaves of Withania somnifera Protect RA Differentiated C6 and IMR-32 Cells against Glutamate-Induced Excitotoxicity
por: Kataria, Hardeep, et al.
Publicado: (2012)

Ashwagandha Leaf Derived Withanone Protects Normal Human Cells Against the Toxicity of Methoxyacetic Acid, a Major Industrial Metabolite
por: Priyandoko, Didik, et al.
Publicado: (2011)

Withania somnifera Water Extract as a Potential Candidate for Differentiation Based Therapy of Human Neuroblastomas
por: Kataria, Hardeep, et al.
Publicado: (2013)

Phosphatidylserine Exposed Lipid Bilayer Models for Understanding Cancer Cell Selectivity of Natural Compounds: A Molecular Dynamics Simulation Study
por: Radhakrishnan, Navaneethan, et al.
Publicado: (2022)

Computational and in vitro experimental analyses of the anti-COVID-19 potential of Mortaparib and Mortaparib(Plus)
por: Kumar, Vipul, et al.
Publicado: (2021)

Effect of Ashwagandha Withanolides on Muscle Cell Differentiation
por: Wang, Jia, et al.
Publicado: (2021)

Wild type p53 function in p53(Y220C) mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence
por: Sundar, Durai, et al.
Publicado: (2019)

Merger of Ayurveda and Tissue Culture-Based Functional Genomics: Inspirations from Systems Biology
por: Deocaris, Custer C, et al.
Publicado: (2008)

Evaluation and Selection of Candidate Reference Genes for Normalization of Quantitative RT-PCR in Withania somnifera (L.) Dunal
por: Singh, Varinder, et al.
Publicado: (2015)

A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms
por: Sari, Anissa Nofita, et al.
Publicado: (2022)

WRN Loss Induces Switching of Telomerase-Independent Mechanisms of Telomere Elongation
por: Gocha, April Renee Sandy, et al.
Publicado: (2014)

Selective Killing of Cancer Cells by Ashwagandha Leaf Extract and Its Component Withanone Involves ROS Signaling
por: Widodo, Nashi, et al.
Publicado: (2010)

Water Extract of Ashwagandha Leaves Limits Proliferation and Migration, and Induces Differentiation in Glioma Cells
por: Kataria, Hardeep, et al.
Publicado: (2011)

Folic Acid Receptor-Mediated Targeting Enhances the Cytotoxicity, Efficacy, and Selectivity of Withania somnifera Leaf Extract: In vitro and in vivo Evidence
por: Yu, Yue, et al.
Publicado: (2019)

Computational Insights into the Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl Ester for Treatment of Aberrant-EGFR Driven Lung Cancers
por: Malik, Vidhi, et al.
Publicado: (2021)

Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl ester as ATP-competitive inhibitors of BRAF: A bioinformatics study
por: Malik, Vidhi, et al.
Publicado: (2021)

Computational Identification of BCR-ABL Oncogenic Signaling as a Candidate Target of Withaferin A and Withanone
por: Malik, Vidhi, et al.
Publicado: (2022)

Why is Mortalin a Potential Therapeutic Target for Cancer?
por: Yoon, A-Rum, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sak5gj05t9u7n7p54lnv0ku0iv