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Conversion surgery for initially unresectable extrahepatic biliary tract cancer

BACKGROUNDS/AIMS: Surgical resection is the only curative treatment for biliary tract cancers; however, most patients undergo palliative chemotherapy because they are contraindicated for surgery. Conversion surgery, a treatment strategy for downsizing chemotherapy and subsequent surgical resection,...

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Autores principales: Oh, Moon Young, Kim, Hongbeom, Choi, Yoo Jin, Byun, Yoonhyeong, Han, Youngmin, Kang, Jae Seung, Sohn, Heeju, Lee, Jung Min, Kwon, Wooil, Jang, Jin-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Hepato-Biliary-Pancreatic Surgery 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382869/
https://www.ncbi.nlm.nih.gov/pubmed/34402435
http://dx.doi.org/10.14701/ahbps.2021.25.3.349
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author Oh, Moon Young
Kim, Hongbeom
Choi, Yoo Jin
Byun, Yoonhyeong
Han, Youngmin
Kang, Jae Seung
Sohn, Heeju
Lee, Jung Min
Kwon, Wooil
Jang, Jin-Young
author_facet Oh, Moon Young
Kim, Hongbeom
Choi, Yoo Jin
Byun, Yoonhyeong
Han, Youngmin
Kang, Jae Seung
Sohn, Heeju
Lee, Jung Min
Kwon, Wooil
Jang, Jin-Young
author_sort Oh, Moon Young
collection PubMed
description BACKGROUNDS/AIMS: Surgical resection is the only curative treatment for biliary tract cancers; however, most patients undergo palliative chemotherapy because they are contraindicated for surgery. Conversion surgery, a treatment strategy for downsizing chemotherapy and subsequent surgical resection, is feasible for initially unresectable biliary tract cancers following the introduction of effective chemotherapeutic agents. METHODS: Patients initially diagnosed with unresectable biliary tract cancers, and treated with conversion surgery after palliative chemotherapy between 2013 and 2019, were reviewed retrospectively. RESULTS: Twelve patients underwent conversion surgery after palliative chemotherapy for initially unresectable biliary tract cancers. The final pathological diagnosis included six perihilar cholangiocarcinomas, four distal common bile duct cancers, and two gallbladder cancers. Different chemotherapy regimens were used, but all the patients were treated with gemcitabine at some point during their treatment. The median overall survival was 28 months, which was longer than that of patients treated with isolated palliative chemotherapy in previous studies. CONCLUSIONS: Conversion surgery represents a therapeutic alternative for specific cases of unresectable biliary tract cancers. Palliative chemotherapy for initially unresectable biliary tract cancers is recommended for downsizing the tumor and expanding the indications for surgery. Further studies and clinical trials are required to develop new and effective chemotherapeutic regimens.
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spelling pubmed-83828692021-09-04 Conversion surgery for initially unresectable extrahepatic biliary tract cancer Oh, Moon Young Kim, Hongbeom Choi, Yoo Jin Byun, Yoonhyeong Han, Youngmin Kang, Jae Seung Sohn, Heeju Lee, Jung Min Kwon, Wooil Jang, Jin-Young Ann Hepatobiliary Pancreat Surg Original Article BACKGROUNDS/AIMS: Surgical resection is the only curative treatment for biliary tract cancers; however, most patients undergo palliative chemotherapy because they are contraindicated for surgery. Conversion surgery, a treatment strategy for downsizing chemotherapy and subsequent surgical resection, is feasible for initially unresectable biliary tract cancers following the introduction of effective chemotherapeutic agents. METHODS: Patients initially diagnosed with unresectable biliary tract cancers, and treated with conversion surgery after palliative chemotherapy between 2013 and 2019, were reviewed retrospectively. RESULTS: Twelve patients underwent conversion surgery after palliative chemotherapy for initially unresectable biliary tract cancers. The final pathological diagnosis included six perihilar cholangiocarcinomas, four distal common bile duct cancers, and two gallbladder cancers. Different chemotherapy regimens were used, but all the patients were treated with gemcitabine at some point during their treatment. The median overall survival was 28 months, which was longer than that of patients treated with isolated palliative chemotherapy in previous studies. CONCLUSIONS: Conversion surgery represents a therapeutic alternative for specific cases of unresectable biliary tract cancers. Palliative chemotherapy for initially unresectable biliary tract cancers is recommended for downsizing the tumor and expanding the indications for surgery. Further studies and clinical trials are required to develop new and effective chemotherapeutic regimens. The Korean Association of Hepato-Biliary-Pancreatic Surgery 2021-08-31 2021-08-31 /pmc/articles/PMC8382869/ /pubmed/34402435 http://dx.doi.org/10.14701/ahbps.2021.25.3.349 Text en Copyright © 2021 by The Korean Association of Hepato-Biliary-Pancreatic Surgery https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Oh, Moon Young
Kim, Hongbeom
Choi, Yoo Jin
Byun, Yoonhyeong
Han, Youngmin
Kang, Jae Seung
Sohn, Heeju
Lee, Jung Min
Kwon, Wooil
Jang, Jin-Young
Conversion surgery for initially unresectable extrahepatic biliary tract cancer
title Conversion surgery for initially unresectable extrahepatic biliary tract cancer
title_full Conversion surgery for initially unresectable extrahepatic biliary tract cancer
title_fullStr Conversion surgery for initially unresectable extrahepatic biliary tract cancer
title_full_unstemmed Conversion surgery for initially unresectable extrahepatic biliary tract cancer
title_short Conversion surgery for initially unresectable extrahepatic biliary tract cancer
title_sort conversion surgery for initially unresectable extrahepatic biliary tract cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382869/
https://www.ncbi.nlm.nih.gov/pubmed/34402435
http://dx.doi.org/10.14701/ahbps.2021.25.3.349
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