Systematic Evolution of Ligands by Exponential Enrichment Technologies and Aptamer-Based Applications: Recent Progress and Challenges in Precision Medicine of Infectious Diseases

Infectious diseases are considered as a pressing challenge to global public health. Accurate and rapid diagnostics tools for early recognition of the pathogen, as well as individualized precision therapy are essential for controlling the spread of infectious diseases. Aptamers, which were screened b...

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Autores principales: Xu, Yixin, Jiang, Xin, Zhou, Yanhong, Ma, Ming, Wang, Minjin, Ying, Binwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383106/
https://www.ncbi.nlm.nih.gov/pubmed/34447741
http://dx.doi.org/10.3389/fbioe.2021.704077
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author Xu, Yixin
Jiang, Xin
Zhou, Yanhong
Ma, Ming
Wang, Minjin
Ying, Binwu
author_facet Xu, Yixin
Jiang, Xin
Zhou, Yanhong
Ma, Ming
Wang, Minjin
Ying, Binwu
author_sort Xu, Yixin
collection PubMed
description Infectious diseases are considered as a pressing challenge to global public health. Accurate and rapid diagnostics tools for early recognition of the pathogen, as well as individualized precision therapy are essential for controlling the spread of infectious diseases. Aptamers, which were screened by systematic evolution of ligands by exponential enrichment (SELEX), can bind to targets with high affinity and specificity so that have exciting potential in both diagnosis and treatment of infectious diseases. In this review, we provide a comprehensive overview of the latest development of SELEX technology and focus on the applications of aptamer-based technologies in infectious diseases, such as targeted drug-delivery, treatments and biosensors for diagnosing. The challenges and the future development in this field of clinical application will also be discussed.
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spelling pubmed-83831062021-08-25 Systematic Evolution of Ligands by Exponential Enrichment Technologies and Aptamer-Based Applications: Recent Progress and Challenges in Precision Medicine of Infectious Diseases Xu, Yixin Jiang, Xin Zhou, Yanhong Ma, Ming Wang, Minjin Ying, Binwu Front Bioeng Biotechnol Bioengineering and Biotechnology Infectious diseases are considered as a pressing challenge to global public health. Accurate and rapid diagnostics tools for early recognition of the pathogen, as well as individualized precision therapy are essential for controlling the spread of infectious diseases. Aptamers, which were screened by systematic evolution of ligands by exponential enrichment (SELEX), can bind to targets with high affinity and specificity so that have exciting potential in both diagnosis and treatment of infectious diseases. In this review, we provide a comprehensive overview of the latest development of SELEX technology and focus on the applications of aptamer-based technologies in infectious diseases, such as targeted drug-delivery, treatments and biosensors for diagnosing. The challenges and the future development in this field of clinical application will also be discussed. Frontiers Media S.A. 2021-08-10 /pmc/articles/PMC8383106/ /pubmed/34447741 http://dx.doi.org/10.3389/fbioe.2021.704077 Text en Copyright © 2021 Xu, Jiang, Zhou, Ma, Wang and Ying. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Xu, Yixin
Jiang, Xin
Zhou, Yanhong
Ma, Ming
Wang, Minjin
Ying, Binwu
Systematic Evolution of Ligands by Exponential Enrichment Technologies and Aptamer-Based Applications: Recent Progress and Challenges in Precision Medicine of Infectious Diseases
title Systematic Evolution of Ligands by Exponential Enrichment Technologies and Aptamer-Based Applications: Recent Progress and Challenges in Precision Medicine of Infectious Diseases
title_full Systematic Evolution of Ligands by Exponential Enrichment Technologies and Aptamer-Based Applications: Recent Progress and Challenges in Precision Medicine of Infectious Diseases
title_fullStr Systematic Evolution of Ligands by Exponential Enrichment Technologies and Aptamer-Based Applications: Recent Progress and Challenges in Precision Medicine of Infectious Diseases
title_full_unstemmed Systematic Evolution of Ligands by Exponential Enrichment Technologies and Aptamer-Based Applications: Recent Progress and Challenges in Precision Medicine of Infectious Diseases
title_short Systematic Evolution of Ligands by Exponential Enrichment Technologies and Aptamer-Based Applications: Recent Progress and Challenges in Precision Medicine of Infectious Diseases
title_sort systematic evolution of ligands by exponential enrichment technologies and aptamer-based applications: recent progress and challenges in precision medicine of infectious diseases
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383106/
https://www.ncbi.nlm.nih.gov/pubmed/34447741
http://dx.doi.org/10.3389/fbioe.2021.704077
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