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Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases

[Image: see text] Acetyl CoA synthetases (ACSs) are Acyl-CoA/NRPS/Luciferase (ANL) superfamily enzymes that couple acetate with CoA to generate acetyl CoA, a key component of central carbon metabolism in eukaryotes and prokaryotes. Normal mammalian cells are not dependent on ACSs, while tumor cells,...

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Detalles Bibliográficos
Autores principales:	Jezewski, Andrew J., Alden, Katy M., Esan, Taiwo E., DeBouver, Nicholas D., Abendroth, Jan, Bullen, Jameson C., Calhoun, Brandy M., Potts, Kristy T., Murante, Daniel M., Hagen, Timothy J., Fox, David, Krysan, Damian J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383264/ https://www.ncbi.nlm.nih.gov/pubmed/34369755 http://dx.doi.org/10.1021/acschembio.1c00484

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