Cargando…
The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam
[Image: see text] The current rise of antibiotic resistant forms of Mycobacterium tuberculosis is a global health threat that calls for new antibiotics. The β-lactamase BlaC of this pathogen prevents the use of β-lactam antibiotics, except in combination with a β-lactamase inhibitor. To understand i...
Autores principales: | van Alen, Ilona, Chikunova, Aleksandra, Safeer, Adil A., Ahmad, Misbha Ud Din, Perrakis, Anastassis, Ubbink, Marcellus |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383266/ https://www.ncbi.nlm.nih.gov/pubmed/34250791 http://dx.doi.org/10.1021/acs.biochem.1c00168 |
Ejemplares similares
-
Conserved residues Glu37 and Trp229 play an essential role in protein folding of β‐lactamase
por: Chikunova, Aleksandra, et al.
Publicado: (2021) -
Two β-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics
por: Elings, Wouter, et al.
Publicado: (2021) -
The roles of highly conserved, non‐catalytic residues in class A β‐lactamases
por: Chikunova, Aleksandra, et al.
Publicado: (2022) -
Mycobacterium tuberculosis β-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis
por: van Alen, Ilona, et al.
Publicado: (2023) -
New Conformations of Acylation Adducts of Inhibitors
of β-Lactamase from Mycobacterium tuberculosis
por: Tassoni, Raffaella, et al.
Publicado: (2019)