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Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration, and α-Deuterated Amide Formation via Metal Ligand Cooperation
[Image: see text] A simple and efficient system for the hydration and α-deuteration of nitriles to form amides, α-deuterated nitriles, and α-deuterated amides catalyzed by a single pincer complex of the earth-abundant manganese capable of metal–ligand cooperation is reported. The reaction is selecti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383274/ https://www.ncbi.nlm.nih.gov/pubmed/34476112 http://dx.doi.org/10.1021/acscatal.1c01748 |
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author | Zhou, Quan-Quan Zou, You-Quan Kar, Sayan Diskin-Posner, Yael Ben-David, Yehoshoa Milstein, David |
author_facet | Zhou, Quan-Quan Zou, You-Quan Kar, Sayan Diskin-Posner, Yael Ben-David, Yehoshoa Milstein, David |
author_sort | Zhou, Quan-Quan |
collection | PubMed |
description | [Image: see text] A simple and efficient system for the hydration and α-deuteration of nitriles to form amides, α-deuterated nitriles, and α-deuterated amides catalyzed by a single pincer complex of the earth-abundant manganese capable of metal–ligand cooperation is reported. The reaction is selective and tolerates a wide range of functional groups, giving the corresponding amides in moderate to good yields. Changing the solvent from tert-butanol to toluene and using D(2)O results in formation of α-deuterated nitriles in high selectivity. Moreover, α-deuterated amides can be obtained in one step directly from nitriles and D(2)O in THF. Preliminary mechanistic studies suggest the transformations contributing toward activation of the nitriles via a metal–ligand cooperative pathway, generating the manganese ketimido and enamido pincer complexes as the key intermediates for further transformations. |
format | Online Article Text |
id | pubmed-8383274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American
Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-83832742021-08-31 Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration, and α-Deuterated Amide Formation via Metal Ligand Cooperation Zhou, Quan-Quan Zou, You-Quan Kar, Sayan Diskin-Posner, Yael Ben-David, Yehoshoa Milstein, David ACS Catal [Image: see text] A simple and efficient system for the hydration and α-deuteration of nitriles to form amides, α-deuterated nitriles, and α-deuterated amides catalyzed by a single pincer complex of the earth-abundant manganese capable of metal–ligand cooperation is reported. The reaction is selective and tolerates a wide range of functional groups, giving the corresponding amides in moderate to good yields. Changing the solvent from tert-butanol to toluene and using D(2)O results in formation of α-deuterated nitriles in high selectivity. Moreover, α-deuterated amides can be obtained in one step directly from nitriles and D(2)O in THF. Preliminary mechanistic studies suggest the transformations contributing toward activation of the nitriles via a metal–ligand cooperative pathway, generating the manganese ketimido and enamido pincer complexes as the key intermediates for further transformations. American Chemical Society 2021-08-03 2021-08-20 /pmc/articles/PMC8383274/ /pubmed/34476112 http://dx.doi.org/10.1021/acscatal.1c01748 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Zhou, Quan-Quan Zou, You-Quan Kar, Sayan Diskin-Posner, Yael Ben-David, Yehoshoa Milstein, David Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration, and α-Deuterated Amide Formation via Metal Ligand Cooperation |
title | Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration,
and α-Deuterated
Amide Formation via Metal Ligand Cooperation |
title_full | Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration,
and α-Deuterated
Amide Formation via Metal Ligand Cooperation |
title_fullStr | Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration,
and α-Deuterated
Amide Formation via Metal Ligand Cooperation |
title_full_unstemmed | Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration,
and α-Deuterated
Amide Formation via Metal Ligand Cooperation |
title_short | Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration,
and α-Deuterated
Amide Formation via Metal Ligand Cooperation |
title_sort | manganese-pincer-catalyzed nitrile hydration, α-deuteration,
and α-deuterated
amide formation via metal ligand cooperation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383274/ https://www.ncbi.nlm.nih.gov/pubmed/34476112 http://dx.doi.org/10.1021/acscatal.1c01748 |
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