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Head injury is associated with tau deposition on PET in MCI and AD patients

INTRODUCTION: Head injuries (HI) are a risk factor for dementia, but the underlying etiology is not fully known. Understanding whether tau might mediate this relationship is important. METHODS: Cognition and tau deposition were compared between 752 individuals with (impaired, n = 302) or without cog...

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Autores principales: Risacher, Shannon L., West, John D., Deardorff, Rachael, Gao, Sujuan, Farlow, Martin R., Brosch, Jared R., Apostolova, Liana G., McAllister, Thomas W., Wu, Yu‐Chien, Jagust, William J., Landau, Susan M., Weiner, Michael W., Saykin, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383323/
https://www.ncbi.nlm.nih.gov/pubmed/34466653
http://dx.doi.org/10.1002/dad2.12230
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author Risacher, Shannon L.
West, John D.
Deardorff, Rachael
Gao, Sujuan
Farlow, Martin R.
Brosch, Jared R.
Apostolova, Liana G.
McAllister, Thomas W.
Wu, Yu‐Chien
Jagust, William J.
Landau, Susan M.
Weiner, Michael W.
Saykin, Andrew J.
author_facet Risacher, Shannon L.
West, John D.
Deardorff, Rachael
Gao, Sujuan
Farlow, Martin R.
Brosch, Jared R.
Apostolova, Liana G.
McAllister, Thomas W.
Wu, Yu‐Chien
Jagust, William J.
Landau, Susan M.
Weiner, Michael W.
Saykin, Andrew J.
author_sort Risacher, Shannon L.
collection PubMed
description INTRODUCTION: Head injuries (HI) are a risk factor for dementia, but the underlying etiology is not fully known. Understanding whether tau might mediate this relationship is important. METHODS: Cognition and tau deposition were compared between 752 individuals with (impaired, n = 302) or without cognitive impairment (CN, n = 450) with amyloid and [(18)F]flortaucipir positron emission tomography, HI history information, and cognitive testing from the Alzheimer's Disease Neuroimaging Initiative and the Indiana Memory and Aging Study. RESULTS: Sixty‐three (38 CN, 25 impaired) reported a history of HI. Higher neuropsychiatric scores and poorer memory were observed in those with a history of HI. Tau was higher in individuals with a history of HI, especially those who experienced a loss of consciousness (LOC). Results were driven by impaired individuals, especially amyloid beta‐positive individuals with history of HI with LOC. DISCUSSION: These findings suggest biological changes, such as greater tau, are associated with HI in individuals with cognitive impairment. Small effect sizes were observed; thus, further studies should replicate and extend these results.
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spelling pubmed-83833232021-08-30 Head injury is associated with tau deposition on PET in MCI and AD patients Risacher, Shannon L. West, John D. Deardorff, Rachael Gao, Sujuan Farlow, Martin R. Brosch, Jared R. Apostolova, Liana G. McAllister, Thomas W. Wu, Yu‐Chien Jagust, William J. Landau, Susan M. Weiner, Michael W. Saykin, Andrew J. Alzheimers Dement (Amst) Neuroimaging INTRODUCTION: Head injuries (HI) are a risk factor for dementia, but the underlying etiology is not fully known. Understanding whether tau might mediate this relationship is important. METHODS: Cognition and tau deposition were compared between 752 individuals with (impaired, n = 302) or without cognitive impairment (CN, n = 450) with amyloid and [(18)F]flortaucipir positron emission tomography, HI history information, and cognitive testing from the Alzheimer's Disease Neuroimaging Initiative and the Indiana Memory and Aging Study. RESULTS: Sixty‐three (38 CN, 25 impaired) reported a history of HI. Higher neuropsychiatric scores and poorer memory were observed in those with a history of HI. Tau was higher in individuals with a history of HI, especially those who experienced a loss of consciousness (LOC). Results were driven by impaired individuals, especially amyloid beta‐positive individuals with history of HI with LOC. DISCUSSION: These findings suggest biological changes, such as greater tau, are associated with HI in individuals with cognitive impairment. Small effect sizes were observed; thus, further studies should replicate and extend these results. John Wiley and Sons Inc. 2021-08-24 /pmc/articles/PMC8383323/ /pubmed/34466653 http://dx.doi.org/10.1002/dad2.12230 Text en © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Neuroimaging
Risacher, Shannon L.
West, John D.
Deardorff, Rachael
Gao, Sujuan
Farlow, Martin R.
Brosch, Jared R.
Apostolova, Liana G.
McAllister, Thomas W.
Wu, Yu‐Chien
Jagust, William J.
Landau, Susan M.
Weiner, Michael W.
Saykin, Andrew J.
Head injury is associated with tau deposition on PET in MCI and AD patients
title Head injury is associated with tau deposition on PET in MCI and AD patients
title_full Head injury is associated with tau deposition on PET in MCI and AD patients
title_fullStr Head injury is associated with tau deposition on PET in MCI and AD patients
title_full_unstemmed Head injury is associated with tau deposition on PET in MCI and AD patients
title_short Head injury is associated with tau deposition on PET in MCI and AD patients
title_sort head injury is associated with tau deposition on pet in mci and ad patients
topic Neuroimaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383323/
https://www.ncbi.nlm.nih.gov/pubmed/34466653
http://dx.doi.org/10.1002/dad2.12230
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