Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure

BACKGROUND: Although extrachromosomal DNA (ecDNA) has been intensively studied for several decades, the mechanisms underlying its tumorigenic effects have been revealed only recently. In most conventional sequencing studies, the high-throughput short-read sequencing largely ignores the epigenetic st...

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Detalles Bibliográficos
Autores principales: Chen, Weitian, Weng, Zhe, Xie, Zhe, Xie, Yeming, Zhang, Chen, Chen, Zhichao, Ruan, Fengying, Wang, Juan, Sun, Yuxin, Fang, Yitong, Guo, Mei, Tong, Yiqin, Li, Yaning, Tang, Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383416/
https://www.ncbi.nlm.nih.gov/pubmed/34425889
http://dx.doi.org/10.1186/s13072-021-00416-5

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