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Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains

BACKGROUND: In the post-GWAS era, there is an unmet need to decode the underpinning genetic etiologies of late-onset Alzheimer’s disease (LOAD) and translate the associations to causation. METHODS: We conducted ATAC-seq profiling using NeuN sorted-nuclei from 40 frozen brain tissues to determine LOA...

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Detalles Bibliográficos
Autores principales:	Barrera, Julio, Song, Lingyun, Gamache, Julia E., Garrett, Melanie E., Safi, Alexias, Yun, Young, Premasinghe, Ivana, Sprague, Daniel, Chipman, Danielle, Li, Jeffrey, Fradin, Hélène, Soldano, Karen, Gordân, Raluca, Ashley-Koch, Allison E., Crawford, Gregory E., Chiba-Falek, Ornit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383438/ https://www.ncbi.nlm.nih.gov/pubmed/34429139 http://dx.doi.org/10.1186/s13024-021-00481-0

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