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Are Oxidative Stress and Inflammation Mediators of Bone Loss Due to Estrogen Deficiency? A Review of Current Evidence

Osteoporosis is one of the major health issues associated with menopause-related estrogen deficiency. Various reports suggest that the hormonal changes related to menopausal transition may lead to the derangement of redox homeostasis and ultimately oxidative stress. Estrogen deficiency and oxidative...

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Autores principales: Mohamad, Nur-Vaizura, Ima-Nirwana, Soelaiman, Chin, Kok-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383467/
https://www.ncbi.nlm.nih.gov/pubmed/32496996
http://dx.doi.org/10.2174/1871530320666200604160614
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author Mohamad, Nur-Vaizura
Ima-Nirwana, Soelaiman
Chin, Kok-Yong
author_facet Mohamad, Nur-Vaizura
Ima-Nirwana, Soelaiman
Chin, Kok-Yong
author_sort Mohamad, Nur-Vaizura
collection PubMed
description Osteoporosis is one of the major health issues associated with menopause-related estrogen deficiency. Various reports suggest that the hormonal changes related to menopausal transition may lead to the derangement of redox homeostasis and ultimately oxidative stress. Estrogen deficiency and oxidative stress may enhance the expression of genes involved in inflammation. All these factors may contribute, in synergy, to the development of postmenopausal osteoporosis. Previous studies suggest that estrogen may act as an antioxidant to protect the bone against oxidative stress, and as an anti-inflammatory agent in suppressing pro-inflammatory and pro-osteoclastic cytokines. Thus, the focus of the current review is to examine the relationship between estrogen deficiency, oxidative stress and inflammation, and the impacts of these phenomena on skeletal health in postmenopausal women.
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spelling pubmed-83834672021-09-07 Are Oxidative Stress and Inflammation Mediators of Bone Loss Due to Estrogen Deficiency? A Review of Current Evidence Mohamad, Nur-Vaizura Ima-Nirwana, Soelaiman Chin, Kok-Yong Endocr Metab Immune Disord Drug Targets Article Osteoporosis is one of the major health issues associated with menopause-related estrogen deficiency. Various reports suggest that the hormonal changes related to menopausal transition may lead to the derangement of redox homeostasis and ultimately oxidative stress. Estrogen deficiency and oxidative stress may enhance the expression of genes involved in inflammation. All these factors may contribute, in synergy, to the development of postmenopausal osteoporosis. Previous studies suggest that estrogen may act as an antioxidant to protect the bone against oxidative stress, and as an anti-inflammatory agent in suppressing pro-inflammatory and pro-osteoclastic cytokines. Thus, the focus of the current review is to examine the relationship between estrogen deficiency, oxidative stress and inflammation, and the impacts of these phenomena on skeletal health in postmenopausal women. Bentham Science Publishers 2020-11 2020-11 /pmc/articles/PMC8383467/ /pubmed/32496996 http://dx.doi.org/10.2174/1871530320666200604160614 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Mohamad, Nur-Vaizura
Ima-Nirwana, Soelaiman
Chin, Kok-Yong
Are Oxidative Stress and Inflammation Mediators of Bone Loss Due to Estrogen Deficiency? A Review of Current Evidence
title Are Oxidative Stress and Inflammation Mediators of Bone Loss Due to Estrogen Deficiency? A Review of Current Evidence
title_full Are Oxidative Stress and Inflammation Mediators of Bone Loss Due to Estrogen Deficiency? A Review of Current Evidence
title_fullStr Are Oxidative Stress and Inflammation Mediators of Bone Loss Due to Estrogen Deficiency? A Review of Current Evidence
title_full_unstemmed Are Oxidative Stress and Inflammation Mediators of Bone Loss Due to Estrogen Deficiency? A Review of Current Evidence
title_short Are Oxidative Stress and Inflammation Mediators of Bone Loss Due to Estrogen Deficiency? A Review of Current Evidence
title_sort are oxidative stress and inflammation mediators of bone loss due to estrogen deficiency? a review of current evidence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383467/
https://www.ncbi.nlm.nih.gov/pubmed/32496996
http://dx.doi.org/10.2174/1871530320666200604160614
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