Two Acute Liver Injuries in a Patient With Malnutrition

Chronic starvation and refeeding have been associated with liver injury (LI). We present a patient with anorexia nervosa who exhibited both phenomena of malnutrition-related LI. At presentation, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated at 154 and 136 U/L, res...

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Autores principales: Su, Amanda, Choe, Monica, Birkness, Jacqueline E., Limketkai, Berkeley, Chen, Po-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383592/
https://www.ncbi.nlm.nih.gov/pubmed/34434480
http://dx.doi.org/10.14740/jmc3713
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author Su, Amanda
Choe, Monica
Birkness, Jacqueline E.
Limketkai, Berkeley
Chen, Po-Hung
author_facet Su, Amanda
Choe, Monica
Birkness, Jacqueline E.
Limketkai, Berkeley
Chen, Po-Hung
author_sort Su, Amanda
collection PubMed
description Chronic starvation and refeeding have been associated with liver injury (LI). We present a patient with anorexia nervosa who exhibited both phenomena of malnutrition-related LI. At presentation, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated at 154 and 136 U/L, respectively, and rose rapidly to peaks of 750 and 638 U/L, respectively, as nutrition was introduced. Mechanisms of starvation-related LI include impaired degradation and secretion of lipids, as well as starvation-induced autophagy. LI during refeeding may be related to rapid increase in glucose availability. These phenomena are crucial to consider in patients with chronic starvation undergoing refeeding.
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spelling pubmed-83835922021-08-24 Two Acute Liver Injuries in a Patient With Malnutrition Su, Amanda Choe, Monica Birkness, Jacqueline E. Limketkai, Berkeley Chen, Po-Hung J Med Cases Case Report Chronic starvation and refeeding have been associated with liver injury (LI). We present a patient with anorexia nervosa who exhibited both phenomena of malnutrition-related LI. At presentation, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated at 154 and 136 U/L, respectively, and rose rapidly to peaks of 750 and 638 U/L, respectively, as nutrition was introduced. Mechanisms of starvation-related LI include impaired degradation and secretion of lipids, as well as starvation-induced autophagy. LI during refeeding may be related to rapid increase in glucose availability. These phenomena are crucial to consider in patients with chronic starvation undergoing refeeding. Elmer Press 2021-08 2021-07-03 /pmc/articles/PMC8383592/ /pubmed/34434480 http://dx.doi.org/10.14740/jmc3713 Text en Copyright 2021, Su et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Su, Amanda
Choe, Monica
Birkness, Jacqueline E.
Limketkai, Berkeley
Chen, Po-Hung
Two Acute Liver Injuries in a Patient With Malnutrition
title Two Acute Liver Injuries in a Patient With Malnutrition
title_full Two Acute Liver Injuries in a Patient With Malnutrition
title_fullStr Two Acute Liver Injuries in a Patient With Malnutrition
title_full_unstemmed Two Acute Liver Injuries in a Patient With Malnutrition
title_short Two Acute Liver Injuries in a Patient With Malnutrition
title_sort two acute liver injuries in a patient with malnutrition
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383592/
https://www.ncbi.nlm.nih.gov/pubmed/34434480
http://dx.doi.org/10.14740/jmc3713
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