Cargando…

Role of C5a and C5aR in doxorubicin-induced cardiomyocyte senescence

Doxorubicin (DOX) is an efficacious antineoplastic drug; however, its use is limited due to its cardiotoxicity. Cardiomyocyte senescence is considered to be a key factor in the development of DOX-related cardiomyopathy. Complement component 5a (C5a) and the C5a receptor (C5aR) have been reported to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wen, Yahui, Shen, Feiyan, Wu, Haibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383765/ https://www.ncbi.nlm.nih.gov/pubmed/34504568 http://dx.doi.org/10.3892/etm.2021.10548

Ejemplares similares

Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections
por: Muenstermann, Marcel, et al.
Publicado: (2019)

Testosterone Antagonizes Doxorubicin‐Induced Senescence of Cardiomyocytes
por: Altieri, Paola, et al.
Publicado: (2016)

C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis
por: Zheng, Quan-you, et al.
Publicado: (2019)

The Controversial C5a Receptor C5aR2: Its Role in Health and Disease
por: Zhang, Ting, et al.
Publicado: (2017)

Role of C5aR1 and C5L2 Receptors in Ischemia-Reperfusion Injury
por: Arias-Cabrales, Carlos, et al.
Publicado: (2021)

The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist
por: Li, Xaria X., et al.
Publicado: (2021)

Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors
por: Colley, Caroline S., et al.
Publicado: (2017)

C5a and C5aR are elevated in joints of rheumatoid and psoriatic arthritis patients, and C5aR blockade attenuates leukocyte migration to synovial fluid
por: Hornum, Lars, et al.
Publicado: (2017)

Time-dependent C5a and C5aR expression in dental pulp cells following stimulation with LTA and LPS
por: Liu, Mingyue, et al.
Publicado: (2019)

The Complement Receptors C3aR and C5aR Are a New Class of Immune Checkpoint Receptor in Cancer Immunotherapy
por: Wang, Yu, et al.
Publicado: (2019)

C5 deficiency and C5a or C5aR blockade protects against cerebral malaria
por: Patel, Samir N., et al.
Publicado: (2008)

The complement C3a-C3aR and C5a-C5aR pathways promote viability and inflammation of human retinal pigment epithelium cells by targeting NF-κB signaling
por: Luo, Shasha, et al.
Publicado: (2022)

The role of C5a-C5aR1 axis in bone pathophysiology: A mini-review
por: Ruocco, Anna, et al.
Publicado: (2022)

Corrigendum to “The Controversial C5a Receptor C5aR2: Its Role in Health and Disease”
por: Zhang, Ting, et al.
Publicado: (2017)

Down-Regulation of C3aR/C5aR Inhibits Cell Proliferation and EMT in Hepatocellular Carcinoma
por: Chen, Bendong, et al.
Publicado: (2020)

Attenuation of cGVHD by C5a/C5aR blockade is associated with increased frequency of Treg
por: Wang, Yulian, et al.
Publicado: (2017)

C3aR and C5aR1 act as key regulators of human and mouse β-cell function
por: Atanes, Patricio, et al.
Publicado: (2017)

Apigenin inhibits C5a-induced proliferation of human nasopharyngeal carcinoma cells through down-regulation of C5aR
por: Zhang, Yanshu, et al.
Publicado: (2018)

C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli
por: Li, Ke, et al.
Publicado: (2017)

The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics
por: Woodruff, Trent M., et al.
Publicado: (2020)

Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis
por: Carvelli, Julien, et al.
Publicado: (2020)

Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
por: Carvalho, Klebea, et al.
Publicado: (2022)

Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome
por: McCullough, Rebecca L., et al.
Publicado: (2018)

Association of Immune and Metabolic Receptors C5aR and C5L2 with Adiposity in Women
por: Poursharifi, Pegah, et al.
Publicado: (2014)

Dexrazoxane Protects Cardiomyocyte from Doxorubicin-Induced Apoptosis by Modulating miR-17-5p
por: Yu, Xiaoxue, et al.
Publicado: (2020)

Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection
por: Horst, Sarah A., et al.
Publicado: (2015)

Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients
por: Emtenani, Shirin, et al.
Publicado: (2022)

Differential effects of C5a on human and mouse mast cells may be mediated by C5aR and C5L2
por: Pundir, P, et al.
Publicado: (2010)

Emerging Approaches for the Management of Chemotherapy-Induced Peripheral Neuropathy (CIPN): Therapeutic Potential of the C5a/C5aR Axis
por: Spera, Maria C., et al.
Publicado: (2022)

Adenovirus-Mediated In Vivo Silencing of Anaphylatoxin Receptor C5aR
por: Sun, Lei, et al.
Publicado: (2006)

The Model Structures of the Complement Component 5a Receptor (C5aR) Bound to the Native and Engineered (h)C5a
por: Sahoo, Amita Rani, et al.
Publicado: (2018)

C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera
por: Silva de França, Felipe, et al.
Publicado: (2021)

C5‐C5aR1‐mediated immune responses during fungal infection: Clinical and translational implications
por: Desai, Jigar V., et al.
Publicado: (2023)

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair
por: Kovtun, Anna, et al.
Publicado: (2017)

Mechanism of activation and biased signaling in complement receptor C5aR1
por: Feng, Yuying, et al.
Publicado: (2023)

Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19
por: Apostolidis, Sokratis A., et al.
Publicado: (2022)

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19
por: Apostolidis, Sokratis A., et al.
Publicado: (2021)

Pan-Cancer Analysis of Immune Complement Signature C3/C5/C3AR1/C5AR1 in Association with Tumor Immune Evasion and Therapy Resistance
por: Lawal, Bashir, et al.
Publicado: (2021)

Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1
por: Zhang, Sheng, et al.
Publicado: (2021)

Acetylation of Atp5f1c Mediates Cardiomyocyte Senescence via Metabolic Dysfunction in Radiation-Induced Heart Damage
por: Zeng, Zhimin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5gc50gig37c0jd9eqh8cnvdvun